RETRACTED: Resveratrol attenuates inflammation and reduces matrix-metalloprotease expression by inducing autophagy via suppressing the Wnt/-catenin signaling pathway in IL-1-induced osteoarthritis chondrocytes (Retracted article. See vol. 11, pg. 4209, 2021)

Resveratrol (Res), a naturally occurring polyphenolic compound, has been reported to exert many biological effects like anti-inflammatory and anti-oxidant effects. In this study, we investigated the role of Res on IL-1-induced osteoarthritis (OA) chondrocytes and its possible mechanism. Results demonstrated that Res suppressed IL-1-induced IL-1, IL-6 and TNF- production in a dose-dependent manner. Res also decreased MMP-1, MMP-3 and MMP-13 production in IL-1-induced OA chondrocytes. These results suggested that Res suppressed IL-1-induced inflammation and matrix-metalloproteases (MMP) expression in OA chondrocytes. In addition, Res was found to reverse the decreased autophagy level through increasing the expression of Beclin1, LC3 II/I ratio and LC3(+) puncta in IL-1-induced OA chondrocytes. Inhibition of autophagy by 3-methyladenine (3-MA) abolished the inhibitory effect of Res on inflammation and MMP expression in IL-1-induced OA chondrocytes. Moreover, the Wnt/-catenin signaling pathway was activated in IL-1-induced OA chondrocytes. However, Res was found to suppress this activated Wnt/-catenin signaling pathway. Activation of the Wnt/-catenin signaling pathway counteracted the promoted effect on autophagy and inhibitory effect on inflammation and MMP expression of Res in IL-1-induced OA chondrocytes. Taken together, our data demonstrated that Res attenuated inflammation and reduced MMP expression through inducing autophagy via inhibiting the Wnt/-catenin signaling pathway in IL-1-induced OA chondrocytes. Res may be used as a potential therapeutic agent for OA treatment.