A General and Efficient Synthesis of Pyrazoles Catalyzed by Sc(OTf)3 under Solvent-Free Conditions

被引：40

作者：

Xiong, Wei ^{[1
]}

Chen, Jiu-Xi ^{[1
]}

Liu, Miao-Chang ^{[1
]}

Ding, Jin-Chang ^{[1
]}

Wu, Hua-Yue ^{[1
]}

Su, Wei-Ke ^{[1
,2
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325027, Peoples R China

[2] Zhejiang Univ Technol, Coll Pharmaceut Sci, Zhejiang Key Lab Pharmaceut Engn, Hangzhou 310014, Zhejiang, Peoples R China

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2009年 / 20卷 / 02期

基金：

中国国家自然科学基金;

关键词：

scandium(III) triflate; pyrazoles; 1,3-diketones; hydrazines; hydrazides; solvent-free; BETA-AMINO ESTERS; ONE-POT SYNTHESIS; GALLIUM(III) TRIFLATE; SELECTIVE SYNTHESIS; BIOLOGICAL-ACTIVITY; IONIC LIQUIDS; DERIVATIVES; INHIBITORS; KETONES; WATER;

D O I：

10.1590/S0103-50532009000200023

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pyrazoles were prepared in excellent yields via solventless condensation of various 1,3-diketones ((RCOCHXCOCH3)-C-1, R-1 = Me, Ph; X = H, Me, Cl) and hydrazines, acylhydrazines or sulfonyl hydrazines in the presence of a catalytic amount of Sc(OTf)(3) at room temperature. Additionally, the catalyst could be recovered easily after the reactions and reused without evident loss in activity.

引用

页码：367 / U204

页数：29

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