Second-Generation Histamine H2-Receptor Antagonists with Gastric Mucosal Defensive Properties

被引：14

作者：

Ichikawa, Takafumi ^{[1
]}

Hotta, Kyoko ^{[1
]}

Ishihara, Kazuhiko ^{[2
]}

机构：

[1] Kitasato Univ, Sch Med, Dept Biochem, Kanagawa 2288555, Japan

[2] Kitasato Univ, Grad Sch Med Sci, Dept Biochem Regulat, Kanagawa 2288555, Japan

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 05期

关键词：

Calcitonin gene-related peptide (CGRP); capsaicin-sensitive nerves; gastroprotective action; histamine H.(2).-receptor antagonists; lafutidine; mucin; roxatidine; structure-activity relationship; GENE-RELATED PEPTIDE; 2(H-2) RECEPTOR ANTAGONIST; SENSITIVE AFFERENT NEURONS; NEURAL EMERGENCY SYSTEM; MUCIN BIOSYNTHESIS; NITRIC-OXIDE; GASTROPROTECTIVE ACTIVITY; ECABET SODIUM; PHARMACOLOGICAL EVALUATION; HELICOBACTER-PYLORI;

D O I：

10.2174/138955709788167646

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Unlike the earlier agents in this class, certain of the newer histamine H.(2).-receptor antagonists (so-called second-generation H.(2).-receptor antagonists) have recently been reported to promote gastric mucosal defenses. We review herein the structure, specificity, and mechanisms of these agents with a special focus on their cytoprotective/gastroprotective actions.

引用

页码：581 / 589

页数：9

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