Herbal Composition LI73014F2 Alleviates Articular Cartilage Damage and Inflammatory Response in Monosodium Iodoacetate-Induced Osteoarthritis in Rats

被引：11

作者：

Kim, Hae Lim ^{[1
]}

Lee, Hae Jin ^{[1
]}

Lee, Dong-Ryung ^{[2
]}

Choi, Bong-Keun ^{[2
]}

Yang, Seung Hwan ^{[1
]}

机构：

[1] Chonnam Natl Univ, Dept Biotechnol, Yeosu 59626, South Korea

[2] Nutrapharm Tech, Seongnam 13201, Gyunggi, South Korea

来源：

MOLECULES | 2020年 / 25卷 / 22期

关键词：

Boswellia serrata extracts; Terminalia chebula fruit extracts; Curcuma longa rhizome extracts; osteoarthritis; cartilage degradation; inflammatory response; EFFICACY; INHIBITOR; EXTRACTS; PAIN;

D O I：

10.3390/molecules25225467

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this study was to determine the anti-osteoarthritic effects of LI73014F2, which consists of Terminalia chebula fruit, Curcuma longa rhizome, and Boswellia serrata gum resin in a 2:1:2 ratio, in the monosodium iodoacetate (MIA)-induced osteoarthritis (OA) rat model. LI73014F2 was orally administered once per day for three weeks. Weight-bearing distribution and arthritis index (AI) were measured once per week to confirm the OA symptoms. Synovial membrane, proteoglycan layer, and cartilage damage were investigated by histological examination, while synovial fluid interleukin-1 beta level was analyzed using a commercial kit. Levels of pro-inflammatory mediators/cytokines and matrix metalloproteinases (MMPs) in the cartilage tissues were investigated to confirm the anti-osteoarthritic effects of LI73014F2. LI73014F2 significantly inhibited the MIA-induced increase in OA symptoms, synovial fluid cytokine, cartilage damage, and expression levels of pro-inflammatory mediators/cytokines and MMPs in the articular cartilage. These results suggest that LI73014F2 exerts anti-osteoarthritic effects by regulating inflammatory cytokines and MMPs in MIA-induced OA rats.

引用

页数：14

共 39 条

[1] A Review on Potential Mechanisms of Terminalia chebula in Alzheimer's Disease [J].