Vinylamycin, a new depsipeptide antibiotic, from Streptomyces sp.

被引：33

作者：

Igarashi, M ^{[1
]}

Shida, T ^{[1
]}

Sasaki, Y ^{[1
]}

Kinoshita, N ^{[1
]}

Naganawa, H ^{[1
]}

Hamada, M ^{[1
]}

Takeuchi, T ^{[1
]}

机构：

[1] Inst Microbial Chem, Shinagawa Ku, Tokyo 141, Japan

来源：

JOURNAL OF ANTIBIOTICS | 1999年 / 52卷 / 10期

关键词：

D O I：

10.7164/antibiotics.52.873

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new depsipeptide antibiotic, vinylamycin, was isolated from the culture broth of an actinomycete strain. The producing organism, designated MI982-63F1, was identified as a member of Streptomyces. Vinylamycin was isolated from the culture broth by extraction with EtOAc and purified by crystallization from EtOAc. The structure of vinylamycin was determined by Spectroscopic analysis and degradation studies. Vinylamycin showed antimicrobial activities against Gram-positive bacteria including MRSA.

引用

页码：873 / 879

页数：7

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