CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

被引：1103

作者：

DeNardo, David G. ^{[1
]}

Barreto, Jairo B. ^{[1
]}

Andreu, Pauline ^{[1
]}

Vasquez, Lesley ^{[1
,4
]}

Tawfik, David ^{[1
,2
]}

Kolhatkar, Nikita ^{[1
]}

Coussens, Lisa M. ^{[1
,3
]}

机构：

[1] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Sch Med, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Heleh Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

[4] San Francisco State Univ, San Francisco, CA 94132 USA

来源：

CANCER CELL | 2009年 / 16卷 / 02期

关键词：

TUMOR-ASSOCIATED MACROPHAGES; BREAST-CANCER; GENE-EXPRESSION; MOUSE MODEL; KAPPA-B; CARCINOGENESIS; INFLAMMATION; PROGRESSION; INTERLEUKIN-4; ACTIVATION;

D O I：

10.1016/j.ccr.2009.06.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

During breast cancer development, increased presence of leukocytes in neoplastic stroma parallels disease progression; however, the functional significance of leukocytes in regulating protumor versus antitumor immunity in the breast remains poorly understood. Utilizing the MMTV-PyMT model of mammary carcinogenesis, we demonstrate that IL-4-expressing CD4(+) T lymphocytes indirectly promote invasion and subsequent metastasis of mammary adenocarcinomas by directly regulating the phenotype and effector function of tumor-associated CD11b(+)Gr1(-)F4/80(+) macrophages that in turn enhance metastasis through activation of epidermal growth factor receptor signaling in malignant mammary epithelial cells. Together, these data indicate that antitumor acquired immune programs can be usurped in protumor microenvironments and instead promote malignancy by engaging cellular components of the innate immune system functionally involved in regulating epithelial cell behavior.

引用

页码：91 / 102

页数：12

共 42 条

[41] Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors [J].

Wyckoff, Jeffrey B. ;

Wang, Yarong ;

Lin, Elaine Y. ;

Li, Jiu-Feng ;

Goswami, Sumanta ;

Stanley, E. Richard ;

Segall, Jeffrey E. ;

Pollard, Jeffrey W. ;

Condeelis, John .

CANCER RESEARCH, 2007, 67 (06) :2649-2656

[42] Abrogation of TGFβ signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis [J].

Yang, Li ;

Huang, Jianhua ;

Ren, Xiubao ;

Gorska, Agnieszka E. ;

Chytil, Anna ;

Aakre, Mary ;

Carbone, David P. ;

Matrisian, Lynn M. ;

Richmond, Ann ;

Lin, P. Charles ;

Mosesl, Harold L. .

CANCER CELL, 2008, 13 (01) :23-35

← 1 2 3 4 5 →