Sexual dimorphism in vestibular function and dysfunction

被引:42
作者
Smith, Paul F. [1 ,2 ,3 ,4 ]
Agrawal, Yuri [5 ]
Darlington, Cynthia L. [1 ,2 ,3 ,4 ]
机构
[1] Univ Otago, Dept Pharmacol & Toxicol, Sch Biomed Sci, Med Sch, Dunedin, New Zealand
[2] Univ Otago, Med Sch, Brain Hlth Res Ctr, Dunedin, New Zealand
[3] Brain Res New Zealand, Auckland, New Zealand
[4] Univ Auckland, Eisdell Moore Ctr Hearing & Balance Res, Auckland, New Zealand
[5] Johns Hopkins Sch Med, Dept Otolaryngol Head & Neck Surg, Baltimore, MD USA
关键词
estrogen; gender differences; sex differences; vestibular system; MOTION SICKNESS SUSCEPTIBILITY; PAROXYSMAL POSITIONAL VERTIGO; EVOKED MYOGENIC POTENTIALS; MENIERES-DISEASE; EPIDEMIOLOGIC SURVEY; POSTURAL STABILITY; GENDER-DIFFERENCES; NORMATIVE DATA; AGE; BRAIN;
D O I
10.1152/jn.00074.2019
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
It has been recognized for some time that females appear to be overrepresented in the incidence of many vestibular disorders, and recent epidemiological studies further support this idea. While it is possible that this is due to a reporting bias, another possibility is that there are actual differences in the incidence of vestibular dysfunction between males and females. If this is true, it could be due to a sexual dimorphism in vestibular function and therefore dysfunction, possibly related to the hormonal differences between females and males, although the higher incidence of vestibular center dot dysfunction in females appears to last long after menopause. Many other neurochemical differences exist between males and females, however, that could be implicated in sexual dimorphism. This review critically explores the possibility of sexual dimorphism in vestibular function and dysfunction, and the implications it may have for the treatment of vestibular disorders.
引用
收藏
页码:2379 / 2391
页数:13
相关论文
共 92 条
[1]   Effect of visual input on postural stability in young adults with chronic motion sensitivity: A controlled cross-sectional study [J].
Alharbi, Ahmad A. ;
Johnson, Eric G. ;
Albalwi, Abdulaziz A. ;
Daher, Noha S. ;
Cordett, Tim K. ;
Ambode, Oluwaseun I. ;
Alshehri, Fahad H. .
JOURNAL OF VESTIBULAR RESEARCH-EQUILIBRIUM & ORIENTATION, 2017, 27 (04) :225-231
[2]   The end of gonad-centric sex determination in mammals [J].
Arnold, Arthur P. .
TRENDS IN GENETICS, 2012, 28 (02) :55-61
[3]   Sexual dimorphism in the medial vestibular nucleus of adult rats: Stereological study [J].
Ayyildiz, Mustafa ;
Kozan, Ramazan ;
Agar, Erdal ;
Kaplan, Suleyman .
ANATOMICAL SCIENCE INTERNATIONAL, 2008, 83 (03) :131-139
[4]   Female rats are not more variable than male rats: a meta-analysis of neuroscience studies [J].
Becker, Jill B. ;
Prendergast, Brian J. ;
Liang, Jing W. .
Biology of Sex Differences, 2016, 7
[5]   Vestibular vertigo and comorbid cognitive and psychiatric impairment: the 2008 National Health Interview Survey [J].
Bigelow, Robin T. ;
Semenov, Yevgeniy R. ;
du Lac, Sascha ;
Hoffman, Howard J. ;
Agrawal, Yuri .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2016, 87 (04) :367-372
[6]   Maternal susceptibility to nausea and vomiting of pregnancy: Is the vestibular system involved? [J].
Black, FO .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2002, 186 (05) :S204-S209
[7]   Strain and Sex Differences in the Vestibular and Systemic Toxicity of 3,3′-Iminodipropionitrile in Mice [J].
Boadas-Vaello, Pere ;
Sedo-Cabezon, Lara ;
Verdu, Enrique ;
Llorens, Jordi .
TOXICOLOGICAL SCIENCES, 2017, 156 (01) :109-122
[8]   An antisense oligonucleotide to brain-derived neurotrophic factor delays postural compensation following unilateral labyrinthectomy in guinea pig [J].
Bolger, C ;
Sansom, AJ ;
Smith, PF ;
Darlington, CL .
NEUROREPORT, 1999, 10 (07) :1485-1488
[9]   Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans [J].
Brandt, T ;
Schautzer, F ;
Hamilton, DA ;
Brüning, R ;
Markowitsch, HJ ;
Kalla, R ;
Darlington, C ;
Smith, P ;
Strupp, M .
BRAIN, 2005, 128 :2732-2741
[10]   Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice [J].
Carroll, Jenna C. ;
Rosario, Emily R. ;
Chang, Lilly ;
Stanczyk, Frank Z. ;
Oddo, Salvatore ;
LaFerla, Frank M. ;
Pike, Christian J. .
JOURNAL OF NEUROSCIENCE, 2007, 27 (48) :13357-13365