Aurones and Analogues: Promising Heterocyclic Scaffolds for Development of Antioxidant and Antimicrobial Agents

被引:12
作者
Irshad, M. [1 ]
Ali, Q. [1 ]
Iram, F. [2 ]
Ahamad, S. A. [2 ]
Saleem, M. [3 ]
Saadia, M. [4 ]
Batool, M. [5 ]
Kanwal, A. [1 ]
Tabassum, S. [1 ]
机构
[1] Univ Educ Lahore, Div Sci & Technol, Dept Chem, Lahore 54770, Pakistan
[2] Lahore Coll Women Univ, Dept Chem, Lahore 75500, Pakistan
[3] Univ Educ, Dept Chem, DG Khan Campus, Dera Ghazi Khan 32200, Pakistan
[4] Univ Sargodha, Dept Biochem, Sargodha 40100, Pakistan
[5] Univ Punjab, Dept Chem, Lahore 54590, Pakistan
关键词
chalcones; pyrazolic; isoxazolic; aurones; 2 '-hydroxyacetophenone; antioxidant; antimicrobial;
D O I
10.1134/S1070363219070235
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Synthesis of some new multi-functional analogues of 2 '-hydroxy chalcone containing isoxazole and pyrazole functions were synthesized, and their pharmacological activity was tested. Chalcone derivatives were synthesized by the reaction of 2 '-hydroxy acetophenone with various substituted benzaldehydes in a basic medium. Aurones were isolated upon treatment with mercuric acetate. Synthesized chalcones and aurones were converted into the corresponding isoxazole and pyrazole derivatives upon their reaction with hydroxylamine hydrochloride or hydrazine hydrate, respectively. Structures of the compounds were confirmed by spectroscopic methods. All synthesized compounds were tested for antioxidant and antibacterial potential. Some of those demonstrated excellent antioxidant activity, and one product was identified as a promising antimicrobial candidate.
引用
收藏
页码:1519 / 1527
页数:9
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