Concise, asymmetric total synthesis of spirotryprostatin A

被引：66

作者：

Onishi, T ^{[1
]}

Sebahar, PR ^{[1
]}

Williams, RM ^{[1
]}

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

来源：

TETRAHEDRON | 2004年 / 60卷 / 42期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

spirotryprostatin A; dipolar cycloaddition; azomethine ylide;

D O I：

10.1016/j.tet.2004.07.047

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structurally intriguing cell-cycle inhibitor spirotryprostatin A has been synthesized utilizing an azomethine ylide dipolar cycloaddition reaction as the key step. This pentacyclic alkaloid contains a prenylated tryptophan-derived oxindole moiety that has been created in a regiocontrolled and stereocontrolled manner in a single step. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：9503 / 9515

页数：13

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