Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology

被引：212
作者：
Hodgkinson, Conrad P.
Bareja, Akshay
Gomez, Jose A.
Dzau, Victor J.
机构：
[1] Duke Univ, Mandel Ctr Hypertens Res, Med Ctr, Dept Med, Durham, NC 27710 USA
[2] Duke Univ, Duke Cardiovasc Res Ctr, Med Ctr, Durham, NC 27710 USA
来源：
CIRCULATION RESEARCH | 2016年 / 118卷 / 01期
关键词：
fibroblast growth factor; heart diseases; myocardial infarction; regeneration; stem cells; MESENCHYMAL STEM-CELLS; FRIZZLED-RELATED PROTEIN-2; BONE-MARROW-CELLS; ENDOTHELIAL PROGENITOR CELLS; IMPROVES CARDIAC-FUNCTION; ANTIFIBROTIC THERAPEUTIC INTERVENTION; LEFT-VENTRICULAR DYSFUNCTION; ACUTE MYOCARDIAL-INFARCTION; GROWTH-FACTOR-I; ISCHEMIC-MYOCARDIUM;
D O I：
10.1161/CIRCRESAHA.115.305373
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In the past decade, substantial evidence supports the paradigm that stem cells exert their reparative and regenerative effects, in large part, through the release of biologically active molecules acting in a paracrine fashion on resident cells. The data suggest the existence of a tissue microenvironment where stem cell factors influence cell survival, inflammation, angiogenesis, repair, and regeneration in a temporal and spatial manner.
引用
收藏
页码：95 / 107
页数：13
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