Site-Specific Surface Functionalization of Gold Nanorods Using DNA Origami Clamps

被引：83

作者：

Shen, Chenqi ^{[1
,2
]}

Lan, Xiang ^{[1
,2
]}

Lu, Xuxing ^{[1
,2
]}

Meyer, Travis A. ^{[3
,4
]}

Ni, Weihai ^{[1
,2
]}

Ke, Yonggang ^{[3
,4
]}

Wang, Qiangbin ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, Div Nanobiomed, Key Lab Nanobio Interface, Suzhou 215123, Peoples R China

[2] Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, I Lab, Suzhou 215123, Peoples R China

[3] Georgia Tech, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30322 USA

[4] Emory Univ, Emory Sch Med, Atlanta, GA 30322 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 06期

基金：

中国国家自然科学基金;

关键词：

PLASMONIC NANOSTRUCTURES; NANOPARTICLES; NANOCATALYSIS; SCAFFOLDS;

D O I：

10.1021/jacs.5b11566

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Precise control over surface functionalities of nanomaterials offers great opportunities for fabricating complex functional nanoarchitectures but still remains challenging. In this work, we successfully developed a novel strategy to modify a gold nanorod (AuNR) with specific surface recognition sites using a DNA origami clamp. AuNRs were encapsulated by the DNA origami through hybridization of single-stranded DNA on the AuNRs and complementary capture strands inside the clamp. Another set of capture strands on the outside of the clamp create the specific recognition sites on the AuNR surface. By means of this strategy, AuNRs were site specifically modified with gold nanoparticles at the top, middle, and bottom of the surface, respectively, to construct a series of well-defined heterostructures with controlled "chemical valence". Our study greatly expands the utility of DNA origami as a tool for building complex nanoarchitectures and represents a new approach for precise tailoring of nanomaterial surfaces.

引用

页码：1764 / 1767

页数：4

共 33 条

[1] Surface modification of silica nanoparticles to reduce aggregation and nonspecific binding [J].