Fluorescent sensors for the basic metabolic panel enable measurement with a smart phone device over the physiological range

被引:31
作者
Awqatty, Becker [1 ]
Samaddar, Shayak [1 ]
Cash, Kevin J. [1 ]
Clark, Heather A. [1 ]
Dubach, J. Matthew [1 ,2 ]
机构
[1] Northeastern Univ, Dept Pharmaceut Sci, Boston, MA 02115 USA
[2] Northeastern Univ, Boston, MA 02115 USA
关键词
SENSITIVE OPTODE MEMBRANE; ION-SELECTIVE ELECTRODES; CELL-PHONE; GLUCOSE BIOSENSOR; EGGSHELL MEMBRANE; MOBILE PHONE; BULK OPTODES; BLOOD; UREA; MICROSPHERES;
D O I
10.1039/c4an00999a
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The advanced functionality of portable devices such as smart phones provides the necessary hardware to potentially perform complex diagnostic measurements in any setting. Recent research and development have utilized cameras and data acquisition properties of smart phones to create diagnostic approaches for a variety of diseases or pollutants. However, in concentration measurements, such as blood glucose, the performance of handheld diagnostic devices depends largely on the sensing mechanism. To expand measurements to multiple components, often necessary in medical tests, with a single diagnostic device, robust platform based sensors are needed. Here, we developed a suite of dual wavelength fluorescent sensors with response characteristics necessary to measure each component of a basic metabolic panel, a common clinical measurement. Furthermore, the response of these sensors could be measured with a simple optical setup to convert a smart phone into a fluorescence measurement instrument. This approach could be used as a mobile basic metabolic panel measurement system for point of care diagnostics.
引用
收藏
页码:5230 / 5238
页数:9
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