Dihydrotanshinone I inhibits ovarian cancer cell proliferation and migration by transcriptional repression of PIK3CA gene

被引：34
作者：
Wang, Xiaoqing [1 ,2 ,3 ]
Xu, Xiao [1 ]
Jiang, Guoqiang [1 ]
Zhang, Cuili [1 ]
Liu, Likun [1 ]
Kang, Jian [1 ]
Wang, Jing [1 ]
Owusu, Lawrence [1 ]
Zhou, Liye [2 ,3 ]
Zhang, Lin [4 ]
Li, Weiling [4 ]
机构：
[1] Dalian Med Univ, Basic Med Sch, Dept Biotechnol, Dalian, Peoples R China
[2] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
[3] Harvard Med Sch, Boston, MA 02115 USA
[4] Dalian Med Univ, Acad Integrat Med, Dalian, Peoples R China
来源：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2020年 / 24卷 / 19期
基金：
中国国家自然科学基金;
关键词：
dihydrotanshinone I; migration; ovarian cancer; PIK3CA; proliferation; 15,16-DIHYDROTANSHINONE I; INDUCED APOPTOSIS; CHINESE MEDICINE; DOUBLE-BLIND; LUNG-CANCER; STATISTICS; THERAPY; OLAPARIB; EXTRACT; PATHWAY;
D O I：
10.1111/jcmm.15660
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Dihydrotanshinone I (DHTS), extracted from Salvia miltiorrhiza, was found to be the most effective compound of tanshen extracts against cancer cells in our previous studies. However, the therapeutic benefits and underlying mechanisms of DHTS on ovarian cancer remain uncertain. In this study, we demonstrated the cytocidal effects of DHTS on chemosensitive ovarian cancer cells with or without platinum-based chemotherapy. DHTS was able to inhibit proliferation and migration of ovarian cancer cells in vitro and in vivo through modulation of the PI3K/AKT signalling pathways. Combinatorial treatment of DHTS and cisplatin exhibited enhanced DNA damage in ovarian cancer cells. Overall, these findings suggest that DHTS induces ovarian cancer cells death via induction of DNA damage and inhibits ovarian cancer cell proliferation and migration.
引用
收藏
页码：11177 / 11187
页数：11
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