Cascade aza-Prins reactions

被引：12

作者：

Cuprova, Lenka ^{[1
]}

Dobbs, Adrian P. ^{[1
]}

机构：

[1] Univ Greenwich, Sch Sci, Chatham, Kent, England

来源：

ADVANCES IN HETEROCYCLIC CHEMISTRY, VOL 130 | 2020年 / 130卷

关键词：

Prins reaction; Aza-Prins reaction; Aza-silyl-Prins reaction; Piperidine; Tetrahydropyridine; Heterocycle; ION-VINYLSILANE CYCLIZATIONS; PRINS/FRIEDEL-CRAFTS CYCLIZATION; STEREOSELECTIVE-SYNTHESIS; EXPEDITIOUS SYNTHESIS; STEREOCONTROLLED SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; NITROGEN-HETEROCYCLES; EFFICIENT SYNTHESIS; N-HETEROCYCLES; RAPID ACCESS;

D O I：

10.1016/bs.aihch.2019.10.006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Saturated nitrogen-containing heterocycles are the basis of a plethora of natural products, including alkaloids and aza-sugars, and a recent survey also demonstrated that the piperidine ring is the most abundant nitrogen-containing heterocycle in FDA-approved pharmaceutically active and commercially available drugs, being found in 72 drugs. The aza-Prins and related reactions have emerged as a rapid and highly efficient method for the preparation of 6-membered nitrogen-containing heterocycles. This chapter reviews recent developments in the aza-Prins reaction, particularly focussing on reports since 2000.

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页码：251 / 278

页数：28

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