The requirement for manganese and oxygen in the isoniazid-dependent inactivation of Mycobacterium tuberculosis enoyl reductase

被引:58
|
作者
Zabinski, RF [1 ]
Blanchard, JS [1 ]
机构
[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT BIOCHEM, BRONX, NY 10461 USA
关键词
CATALASE-PEROXIDASE GENE; MYCOLIC ACID SYNTHESIS; NEW-YORK-CITY; SUPEROXIDE DISMUTASES; RESISTANT STRAINS; KATG; ETHIONAMIDE; TARGET; INHA;
D O I
10.1021/ja9639731
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:2331 / 2332
页数:2
相关论文
共 41 条
  • [31] The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance
    Banerjee, A
    Sugantino, M
    Sacchettini, JC
    Jacobs, WR
    MICROBIOLOGY-SGM, 1998, 144 : 2697 - 2704
  • [32] Insight into crucial inhibitor-enzyme interaction of arylamides as novel direct inhibitors of the enoyl ACP reductase (InhA) from Mycobacterium tuberculosis: computer-aided molecular design
    Punkvang, Auradee
    Saparpakorn, Patchreenart
    Hannongbua, Supa
    Wolschann, Peter
    Berner, Heinz
    Pungpo, Pornpan
    MONATSHEFTE FUR CHEMIE, 2010, 141 (09): : 1029 - 1041
  • [33] Inhibition of Mycobacterium tuberculosis InhA (Enoyl-acyl carrier protein reductase) by synthetic Chalcones: a molecular modelling analysis and in-vitro evidence
    Dhivya, L. S.
    Sarvesh, Sabarathinam
    Singh, Ankul S.
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2023, 41 (12): : 5399 - 5417
  • [34] Drug repurposing approach against Mycobacterium tuberculosis Enoyl-[acyl-carrier-protein] reductase: insight from molecular dynamics simulations
    Kisten, Kimona
    Kumalo, Hezekiel M.
    Machaba, Kgothatso E.
    Ndagi, Umar
    Mhlongo, Ndumiso N.
    MOLECULAR SIMULATION, 2021, 47 (16) : 1313 - 1325
  • [35] Computer-Aided Design of Orally Bioavailable Pyrrolidine Carboxamide Inhibitors of Enoyl-Acyl Carrier Protein Reductase of Mycobacterium tuberculosis with Favorable Pharmacokinetic Profiles
    Kouassi, Affiba Florance
    Kone, Mawa
    Keita, Melalie
    Esmel, Akori
    Megnassan, Eugene
    N'Guessan, Yao Thomas
    Frecer, Vladimir
    Miertus, Stanislav
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 16 (12) : 29744 - 29771
  • [36] Structure-Based Design of a Novel Class of Potent Inhibitors of InhA, the Enoyl Acyl Carrier Protein Reductase from Mycobacterium Tuberculosis: A Computer Modelling Approach
    Rao, Gita Subba
    Vijayakrishnan, Rajakrishnan
    Kumar, Manoj
    CHEMICAL BIOLOGY & DRUG DESIGN, 2008, 72 (05) : 444 - 449
  • [37] Design and synthesis of Thieno[3, 2-b]pyridinone derivatives exhibiting potent activities against Mycobacterium tuberculosis in vivo by targeting Enoyl-ACP reductase
    Liang, Lihong
    Liu, Zhiyong
    Chen, Jie
    Zha, Qin
    Zhou, Yihuan
    Li, Jun
    Hu, Yangbo
    Chen, Xinwen
    Zhang, Tianyu
    Zhang, Niuniu
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 279
  • [38] 1H and 13C NMR characterization of hemiamidal isoniazid-NAD(H) adducts as possible inhibitors of InhA reductase of Mycobacterium tuberculosis
    Broussy, S
    Coppel, Y
    Nguyen, M
    Bernadou, J
    Meunier, B
    CHEMISTRY-A EUROPEAN JOURNAL, 2003, 9 (09) : 2034 - 2038
  • [39] Pharmacophore mapping, molecular docking, chemical synthesis of some novel pyrrolyl benzamide derivatives and evaluation of their inhibitory activity against enoyl-ACP reductase (InhA) and Mycobacterium tuberculosis
    Joshi, Shrinivas D.
    Dixit, Sheshagiri R.
    Basha, Jeelan
    Kulkarni, V. H.
    Aminabhavi, Tejraj M.
    Nadagouda, Mallikarjuna N.
    Lherbet, Christian
    BIOORGANIC CHEMISTRY, 2018, 81 : 440 - 453
  • [40] Identification of a New Potential Reductase Inhibitor as an Anti-Tubercular Agent for Enoyl-Acp Reductase Inha Gene of Mycobacterium tuberculosis in Comparison with PT70 (5-Hexyl-2-(2-Methylphenoxy) Phenol)
    Soni, Nishant Kumar
    Verma, Chandan Kumar
    INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, 2018, 52 (04) : 691 - 698