Editorial: Once and again - Issues surrounding replication in genetic association studies

被引:130
作者
Hirschhorn, JN
Altshuler, D
机构
[1] Childrens Hosp, Div Genet & Endocrinol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02114 USA
[3] Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA
[4] MIT, Whitehead Ctr Genome Res, Cambridge, MA 02139 USA
[5] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
[6] Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA
关键词
D O I
10.1210/jc.2002-021329
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:4438 / 4441
页数:4
相关论文
共 14 条
  • [1] The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
    Altshuler, D
    Hirschhorn, JN
    Klannemark, M
    Lindgren, CM
    Vohl, MC
    Nemesh, J
    Lane, CR
    Schaffner, SF
    Bolk, S
    Brewer, C
    Tuomi, T
    Gaudet, D
    Hudson, TJ
    Daly, M
    Groop, L
    Lander, ES
    [J]. NATURE GENETICS, 2000, 26 (01) : 76 - 80
  • [2] The structure of haplotype blocks in the human genome
    Gabriel, SB
    Schaffner, SF
    Nguyen, H
    Moore, JM
    Roy, J
    Blumenstiel, B
    Higgins, J
    DeFelice, M
    Lochner, A
    Faggart, M
    Liu-Cordero, SN
    Rotimi, C
    Adeyemo, A
    Cooper, R
    Ward, R
    Lander, ES
    Daly, MJ
    Altshuler, D
    [J]. SCIENCE, 2002, 296 (5576) : 2225 - 2229
  • [3] Molecular screening of the human melanocortin-4 receptor gene: Identification of a missense variant showing no association with obesity, plasma glucose, or insulin
    Gotoda, T
    Scott, J
    Aitman, TJ
    [J]. DIABETOLOGIA, 1997, 40 (08) : 976 - 979
  • [4] Identification and functional analysis of novel human melanocortin-4 receptor variants
    Gu, W
    Tu, ZM
    Kleyn, PW
    Kissebah, A
    Duprat, L
    Lee, J
    Chin, W
    Maruti, S
    Deng, NH
    Fisher, SL
    Franco, LS
    Burn, P
    Yagaloff, KA
    Nathan, J
    Heymsfield, S
    Albu, J
    Pi-Sunyer, FX
    Allison, DB
    [J]. DIABETES, 1999, 48 (03) : 635 - 639
  • [5] A comprehensive review of genetic association studies
    Hirschhorn, JN
    Lohmueller, K
    Byrne, E
    Hirschhorn, K
    [J]. GENETICS IN MEDICINE, 2002, 4 (02) : 45 - 61
  • [6] Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    Huszar, D
    Lynch, CA
    FairchildHuntress, V
    Dunmore, JH
    Fang, Q
    Berkemeier, LR
    Gu, W
    Kesterson, RA
    Boston, BA
    Cone, RD
    Smith, FJ
    Campfield, LA
    Burn, P
    Lee, F
    [J]. CELL, 1997, 88 (01) : 131 - 141
  • [7] Melanocortin 4 receptor sequence variations are seldom a cause of human obesity:: The Swedish obese subjects, the HERITAGE family study, and a Memphis cohort
    Jacobson, P
    Ukkola, O
    Rankinen, T
    Snyder, EE
    Leon, AS
    Rao, DC
    Skinner, JS
    Wilmore, JH
    Lönn, L
    Cowan, GS
    Sjöström, L
    Bouchard, C
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (10) : 4442 - 4446
  • [8] Ohshiro Y, 1999, ANN HUM GENET, V63, P483, DOI 10.1017/S0003480099007782
  • [9] Are rare variants responsible for susceptibility to complex diseases?
    Pritchard, JK
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (01) : 124 - 137
  • [10] The future of genetic studies of complex human diseases
    Risch, N
    Merikangas, K
    [J]. SCIENCE, 1996, 273 (5281) : 1516 - 1517