Phospholipid and sterol analysis of plasma membranes of azole-resistant Candida albicans strains

被引：88

作者：

Löffler, J

Einsele, H

Hebart, H

Schumacher, U

Hrastnik, C

Daum, G

机构：

[1] Univ Tubingen, Med Klin, Abt 2, Lab Prof Dr Med H Einsele, Tubingen, Germany

[2] Univ Tubingen, Inst Hyg, Tubingen, Germany

[3] Graz Univ Technol, Inst Biochem & Lebensmittelchem, Graz, Austria

来源：

FEMS MICROBIOLOGY LETTERS | 2000年 / 185卷 / 01期

关键词：

phospholipid; sterol; plasma membrane; Candida;

D O I：

10.1016/S0378-1097(00)00071-9

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The phospholipid and sterol composition of the plasma membranes of five fluconazole-resistant clinical Candida albicans isolates was compared to that of three fluconazole-sensitive ones. The three azole-sensitive strains tested and four of the five resistant strains did not exhibit any major difference in their phospholipid and sterol composition. The remaining strain (R5) showed a decreased amount of ergosterol and a lower phosphatidylcholine :phosphatidylethanolamine ratio in the plasma membrane. These changes in the plasma membrane lipid and sterol composition may be responsible for an altered uptake of drugs and thus for a reduced intracellular accumulation of fluconazole thereby providing a mechanism for azole resistance. (C) 2000 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：59 / 63

页数：5

共 28 条

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