l-Proline is a sedative regulator of acute stress in the brain of neonatal chicks

被引：50

作者：

Hamasu, K. ^{[1
]}

Haraguchi, T. ^{[1
]}

Kabuki, Y. ^{[1
]}

Adachi, N. ^{[1
]}

Tomonaga, S. ^{[1
]}

Sato, H. ^{[2
]}

Denbow, D. M. ^{[3
]}

Furuse, M. ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Bioresource & Bioenvironm Sci, Lab Adv Anim & Marine Bioresources, Fukuoka 8128581, Japan

[2] Ajinomoto Co Inc, Kawasaki Ku, Kawasaki, Kanagawa 2108681, Japan

[3] Virginia Polytech Inst & State Univ, Dept Anim & Poultry Sci, Blacksburg, VA 24061 USA

来源：

AMINO ACIDS | 2009年 / 37卷 / 02期

基金：

日本学术振兴会;

关键词：

L-Proline; Amino acid; Chick; Stress; Brain; i.c.v; injection; INTRACEREBROVENTRICULAR INJECTION; AMINO-ACIDS; L-SERINE; LIPOGENESIS; HISTAMINE; RECEPTORS; RESPONSES; GLUTAMATE;

D O I：

10.1007/s00726-008-0164-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The purpose of the present study was to clarify the central nervous system function of amino acids during acute stress. In Experiment 1, changes in free amino acid pattern were investigated in the brain of neonatal chicks exposed to either restraint with isolation-induced or fasting stress. l-Proline and l-arginine were decreased in the telencephalon and diencephalon under any stress. Since the central nervous system functions of l-arginine during the stress response has recently been reported, in Experiment 2, the effect of intracerebroventricular injection of l-proline (0.5, 1.0, 2.0 mu mol) during isolation-induced stress was investigated. l-Proline induced sedative and hypnotic effects in a dose-dependent manner. It is suggested that l-proline may have an important role to attenuate the stress response in the central nervous system of chicks.

引用

页码：377 / 382

页数：6

共 23 条

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