Untethered micro-robotic coding of three-dimensional material composition

被引：174

作者：

Tasoglu, S. ^{[1
]}

Diller, E. ^{[2
]}

Guven, S. ^{[1
]}

Sitti, M. ^{[2
]}

Demirci, U. ^{[1
,3
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Dept Med, Div Biomed Engn,Med Sch,Bio Acoust MEMS BAMM Lab, Boston, MA 02115 USA

[2] Carnegie Mellon Univ, Dept Mech Engn, Pittsburgh, PA 15213 USA

[3] Harvard MIT Hlth Sci & Technol, Cambridge, MA 02139 USA

来源：

NATURE COMMUNICATIONS | 2014年 / 5卷

基金：

美国国家科学基金会;

关键词：

MAGNETIC MICROROBOTS;

D O I：

10.1038/ncomms4124

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Complex functional materials with three-dimensional micro-or nano-scale dynamic compositional features are prevalent in nature. However, the generation of three-dimensional functional materials composed of both soft and rigid microstructures, each programmed by shape and composition, is still an unsolved challenge. Here we describe a method to code complex materials in three-dimensions with tunable structural, morphological and chemical features using an untethered magnetic micro-robot remotely controlled by magnetic fields. This strategy allows the micro-robot to be introduced to arbitrary microfluidic environments for remote two-and three-dimensional manipulation. We demonstrate the coding of soft hydrogels, rigid copper bars, polystyrene beads and silicon chiplets into three-dimensional heterogeneous structures. We also use coded microstructures for bottom-up tissue engineering by generating cell-encapsulating constructs.

引用

页数：9

共 28 条

[1] Guided and fluidic self-assembly of microstructures using railed microfluidic channels [J].