Synthesis and biological evaluation of camptothecin substituted norcantharimide derivatives

被引：5

作者：

Lan, Qing ^{[1
]}

Zhou, Yiqi ^{[1
]}

Wang, Xianheng ^{[1
]}

Wang, Yuhe ^{[2
]}

Zhao, Changkuo ^{[1
]}

机构：

[1] Zunyi Med Univ, Dept Med Chem, Zunyi, Guizhou, Peoples R China

[2] Zunyi Med Univ, Affiliated Hosp, Dept Pharm, Zunyi, Guizhou, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 24期

关键词：

Thalidomide; cantharidimide; cnticancer; camptothecin; THALIDOMIDE; METABOLITES;

D O I：

10.1080/14786419.2020.1834546

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this paper, a series of novel derivatives of camptothecin substituted norcantharimide was designed by mimic strategy. These compounds were synthesized in moderate yields by directly coupling CPT with N-amino acid norcantharimides. Their cytotoxicity to four human tumour cell lines (HepG2, BGC-803, SW480 and PANC-1) and normal human cell lines L-O2 and HIEC was evaluated. The synthesized CPT substituted norcantharimide analogs (3g and 3f) showed better anti-hepatocarcinoma activity than CPT. Compounds 3d, 3e, 3g, 3h and 3i also showed strong inhibition activity against BGC803. [GRAPHICS] .

引用

页码：5752 / 5756

页数：5

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