Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy

被引:875
作者
Coulie, Pierre G. [1 ,2 ,3 ,4 ]
Van den Eynde, Benoit J. [1 ,2 ,3 ,4 ]
van der Bruggen, Pierre [1 ,2 ,4 ]
Boon, Thierry [1 ,2 ,3 ]
机构
[1] de Duve Inst, B-1200 Brussels, Belgium
[2] Catholic Univ Louvain, B-1200 Brussels, Belgium
[3] Ludwig Inst Canc Res, B-1200 Brussels, Belgium
[4] WELBIO Walloon Excellence Lifesci & Biotechnol, B-1200 Brussels, Belgium
关键词
MOUSE MASTOCYTOMA P815; HUMAN-MELANOMA ANTIGEN; CELL-MEDIATED CYTOTOXICITY; OPEN READING FRAME; HUMAN GENE MAGE-3; IN-VITRO; INFILTRATING LYMPHOCYTES; CANCER/TESTIS ANTIGEN; SPERM PROTEIN-17; DENDRITIC CELLS;
D O I
10.1038/nrc3670
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In this Timeline, we describe the characteristics of tumour antigens that are recognized by spontaneous T cell responses in cancer patients and the paths that led to their identification. We explain on what genetic basis most, but not all, of these antigens are tumour specific: that is, present on tumour cells but not on normal cells. We also discuss how strategies that target these tumour-specific antigens can lead either to tumour-specific or to crossreactive T cell responses, which is an issue that has important safety implications in immunotherapy. These safety issues are even more of a concern for strategies targeting antigens that are not known to induce spontaneous T cell responses in patients.
引用
收藏
页码:135 / 146
页数:12
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