The impact of aging and physical training on angiogenesis in the musculoskeletal system

被引：3
作者：
Zmudzka, Magdalena [1 ]
Zoladz, Jerzy A. [1 ]
Majerczak, Joanna [1 ]
机构：
[1] Jagiellonian Univ Med Coll, Chair Exercise Physiol & Muscle Bioenerget, Fac Hlth Sci, Krakow, Poland
来源：
PEERJ | 2022年 / 10卷
关键词：
Angiogenesis; Physical training; Muscle-bone crosstalk; Skeletal muscle aging; Bone; aging; Nitric oxide; VEGF; Capillaries; ENDOTHELIAL GROWTH-FACTOR; HUMAN SKELETAL-MUSCLE; THERAPY PROMOTES ANGIOGENESIS; ACUTE MYOCARDIAL-INFARCTION; HYPOXIA-INDUCIBLE FACTOR; VASTUS-LATERALIS MUSCLE; MESSENGER-RNA RESPONSE; NITRIC-OXIDE; BLOOD-FLOW; HABITUAL EXERCISE;
D O I：
10.7717/peerj.14228
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Angiogenesis is the physiological process of capillary growth. It is strictly regulated by the balanced activity of agents that promote the formation of capillaries (pro-angiogenic factors) on the one hand and inhibit their growth on the other hand (anti-angiogenic factors). Capillary rarefaction and insufficient angiogenesis are some of the main causes that limit blood flow during aging, whereas physical training is a potent nonpharmacological method to intensify capillary growth in the musculoskeletal system. The main purpose of this study is to present the current state of knowledge concerning the key signalling molecules implicated in the regulation of skeletal muscle and bone angiogenesis during aging and physical training.
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页数：33
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