Classical and non-classical congenital adrenal hyperplasia: What is the difference in subsequent fertility?

被引：0
|
作者：
Carriere, Camille [1 ,2 ]
Sarfati, Cynthia [1 ,2 ,3 ]
Tejedor, Isabelle [1 ,2 ]
Dulon, Jerome [1 ,2 ]
Chakhtoura, Zeina [1 ,2 ]
Courtillot, Carine [1 ,2 ]
Bachelot, Anne [1 ,2 ,3 ]
机构：
[1] Hop La Pitie Salpetriere, AP HP, IE3M, Dept Endocrinol & Reprod Med, Paris, France
[2] ICAN, Ctr Reference Pathol Gynecol Rares, Ctr Reference Malad Endocriniennes Rares Croissan, Paris, France
[3] Sorbonne Univ, Paris, France
来源：
ANNALES D ENDOCRINOLOGIE | 2022年 / 83卷 / 03期
关键词：
Congenital adrenal hyperplasia; 21 hydroxylase deficiency; Fertility; Pregnancy; REST TUMORS; 21-HYDROXYLASE DEFICIENCY; ADULT MALES; WOMEN; OUTCOMES; MEN; PREGNANCY; COHORT; PREVALENCE; ADOLESCENT;
D O I：
10.1016/j.o.2022.04.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
21-Hydroxylase deficiency (21OHD) is the most common cause of congenital adrenal hyperplasia. Increased production of adrenal-derived androgens and progesterone in 21OHD women interfere with their reproductive function and their fertility in many different ways, depending on the severity of the disease. Sexuality and fertility in women with classic 21OHD is impaired, due to several issues such as disrupted gonadotropic axis due to androgen and progesterone overproduction, and mechanical, psychological factors related to genital surgery. Fertility and fecundity in these women get better over the years. Subfertility seems contrariwise to be relative in non-classic 21OHD women. Before pregnancy, genotyping the partner and genetic counselling is mandatory. (c) 2022 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：181 / 185
页数：5
相关论文
共 50 条
  • [41] Reassessing fecundity in women with classical congenital adrenal hyperplasia (CAH): normal pregnancy rate but reduced fertility rate
    Casteras, Anna
    De Silva, Purnami
    Rumsby, Gillian
    Conway, Gerard S.
    CLINICAL ENDOCRINOLOGY, 2009, 70 (06) : 833 - 837
  • [42] Fertility in patients with nonclassical congenital adrenal hyperplasia
    New, Maria I.
    Ghizzoni, Lucia
    Meyer-Bahlburg, Heino
    Khattab, Ahmed
    Reichman, David
    Rosenwaks, Zev
    FERTILITY AND STERILITY, 2019, 111 (01) : 13 - 20
  • [43] White Matter Microstructural Differences in Youth With Classical Congenital Adrenal Hyperplasia
    Cotter, Devyn L.
    Azad, Anisa
    Cabeen, Ryan P.
    Kim, Mimi S.
    Geffner, Mitchell E.
    Sepehrband, Farshid
    Herting, Megan M.
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2021, 106 (11) : 3196 - 3212
  • [44] Classical forms of congenital adrenal hyperplasia due to 21-hydroxylase deficiency in adults
    Bachelot, Anne
    Chakthoura, Zeina
    Rouxel, Agnes
    Dulon, Jerome
    Touraine, Philippe
    HORMONE RESEARCH, 2008, 69 (04) : 203 - 211
  • [45] Vascular and cardiac function in young adults with classical congenital adrenal hyperplasia
    Wierzbicka-Chmiel, Joanna
    Chmiel, Artur
    Rychlik, Slawomir
    Ogrodowczyk-Bobik, Monika
    Marek, Bogdan
    Kajdaniuk, Dariusz
    ENDOKRYNOLOGIA POLSKA, 2017, 68 (05) : 505 - 511
  • [46] Fertility among women with classical congenital adrenal hyperplasia: Report of seven cases where treatment was started after 9 years of age
    Kulshreshtha, Bindu
    Marumudi, Eunice
    Khurana, Madan Lal
    Kriplani, Alka
    Kinra, Geeta
    Gupta, Denvender K.
    Kucheria, Kiran
    Khadgawat, Rajesh
    Gupta, Nandita
    Seith, Ashu
    Ammini, Ariachery C.
    GYNECOLOGICAL ENDOCRINOLOGY, 2008, 24 (05) : 267 - 272
  • [47] High frequency of non-classical congenital adrenal hyperplasia form among children with persistently elevated levels of 17-hydroxyprogesterone after newborn screening
    Castro, Patricia S.
    Rassi, Tatiana O.
    Araujo, Raquel F.
    Pezzuti, Isabela L.
    Rodrigues, Andresa S.
    Bachega, Tania A. S. S.
    Silva, Ivani N.
    JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 2019, 32 (05) : 499 - 504
  • [48] Sexual function and fertility in adult females and males with congenital adrenal hyperplasia
    Jääskeläinen, J
    Tiitinen, A
    Voutilainen, R
    HORMONE RESEARCH, 2001, 56 (3-4) : 73 - 80
  • [49] Stigma Associated with Classical Congenital Adrenal Hyperplasia in Women's Sexual Lives
    Meyer-Bahlburg, Heino F. L.
    Khuri, Jananne
    Reyes-Portillo, Jazmin
    Ehrhardt, Anke A.
    New, Maria I.
    ARCHIVES OF SEXUAL BEHAVIOR, 2018, 47 (04) : 943 - 951
  • [50] Stigma Associated with Classical Congenital Adrenal Hyperplasia in Women’s Sexual Lives
    Heino F. L. Meyer-Bahlburg
    Jananne Khuri
    Jazmin Reyes-Portillo
    Anke A. Ehrhardt
    Maria I. New
    Archives of Sexual Behavior, 2018, 47 : 943 - 951
12345