Direct access to heterocyclic scaffolds by new multicomponent Ugi-smiles couplings

被引：66

作者：

El Kaim, Laurent ^{[1
]}

Gizolme, Marie ^{[1
]}

Grimaud, Laurence ^{[1
]}

Oble, Julie ^{[1
]}

机构：

[1] Ecole Normale Super Tech Avancees, Lab Chim & Proc, F-75739 Paris 15, France

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 18期

关键词：

D O I：

10.1021/ol061605o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New heterocyclic scaffolds can be easily prepared by the coupling of heteroaromatic phenols (pyridines, pyrimidines) with carbonyl compounds, amines, and isocyanides. This transformation related to the Ugi reaction probably involves a Smiles rearrangement. The scope of this methodology is further extended by the successful use of heterocyclic thiols to form highly functionalized thioamides.

引用

页码：4019 / 4021

页数：3

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