Pentraxin 3: A promising therapeutic target for autoimmune diseases

被引：51
作者：
Wu, Qian [1 ,2 ]
Cao, Fan [3 ]
Tao, Jinhui [4 ]
Li, Xiaomei [4 ]
Zheng, Song Guo [5 ,6 ]
Pan, Hai-Feng [1 ,2 ]
机构：
[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China
[2] Anhui Prov Lab Inflammat & Immune Mediated Dis, 81 Meishan Rd, Hefei, Anhui, Peoples R China
[3] Anhui Med Univ, Sch Clin Med 2, Dept Clin Med, 81 Meishan Rd, Hefei, Anhui, Peoples R China
[4] Univ Sci & Technol China, Affiliated Hosp 1, Dept Rheumatol & Immunol, Hefei, Anhui, Peoples R China
[5] Ohio State Univ, Coll Med, Dept Internal Med, Columbus, OH 43210 USA
[6] Wexner Med Ctr, Columbus, OH 43210 USA
来源：
AUTOIMMUNITY REVIEWS | 2020年 / 19卷 / 12期
基金：
中国国家自然科学基金;
关键词：
SYSTEMIC-LUPUS-ERYTHEMATOSUS; HUMORAL INNATE IMMUNITY; C-REACTIVE PROTEIN; SERUM AMYLOID-P; RECOGNITION RECEPTOR PTX3; CORONARY-ARTERY-DISEASE; RHEUMATOID-ARTHRITIS; APOPTOTIC CELLS; CARDIOVASCULAR BIOMARKER; ANKYLOSING-SPONDYLITIS;
D O I：
10.1016/j.autrev.2020.102584
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Pentraxin 3 (PTX3) is a prototypic humoral soluble pattern recognition molecule that exerts a pivotal role in innate immune response and inflammation, as well as in tissue damage and remodeling. Recently, emerging evidence has revealed that PTX3 is involved in the occurrence and development of various autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), ankylosing spondylitis (AS), systemic sclerosis (SSc), inflammatory bowel disease (IBD), multiple sclerosis (MS) and psoriasis, etc. In this review, we have succinctly summarized the complex immunological functions of PTX3 and mostly focused on recent findings of the pleiotropic activities played by PTX3 in the pathogenesis of autoimmune diseases, aiming at hopefully offering possible future therapeutic alternatives.
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页数：10
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