Pentraxin 3: A promising therapeutic target for autoimmune diseases

被引：51
作者：
Wu, Qian [1 ,2 ]
Cao, Fan [3 ]
Tao, Jinhui [4 ]
Li, Xiaomei [4 ]
Zheng, Song Guo [5 ,6 ]
Pan, Hai-Feng [1 ,2 ]
机构：
[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China
[2] Anhui Prov Lab Inflammat & Immune Mediated Dis, 81 Meishan Rd, Hefei, Anhui, Peoples R China
[3] Anhui Med Univ, Sch Clin Med 2, Dept Clin Med, 81 Meishan Rd, Hefei, Anhui, Peoples R China
[4] Univ Sci & Technol China, Affiliated Hosp 1, Dept Rheumatol & Immunol, Hefei, Anhui, Peoples R China
[5] Ohio State Univ, Coll Med, Dept Internal Med, Columbus, OH 43210 USA
[6] Wexner Med Ctr, Columbus, OH 43210 USA
来源：
AUTOIMMUNITY REVIEWS | 2020年 / 19卷 / 12期
基金：
中国国家自然科学基金;
关键词：
SYSTEMIC-LUPUS-ERYTHEMATOSUS; HUMORAL INNATE IMMUNITY; C-REACTIVE PROTEIN; SERUM AMYLOID-P; RECOGNITION RECEPTOR PTX3; CORONARY-ARTERY-DISEASE; RHEUMATOID-ARTHRITIS; APOPTOTIC CELLS; CARDIOVASCULAR BIOMARKER; ANKYLOSING-SPONDYLITIS;
D O I：
10.1016/j.autrev.2020.102584
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Pentraxin 3 (PTX3) is a prototypic humoral soluble pattern recognition molecule that exerts a pivotal role in innate immune response and inflammation, as well as in tissue damage and remodeling. Recently, emerging evidence has revealed that PTX3 is involved in the occurrence and development of various autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), ankylosing spondylitis (AS), systemic sclerosis (SSc), inflammatory bowel disease (IBD), multiple sclerosis (MS) and psoriasis, etc. In this review, we have succinctly summarized the complex immunological functions of PTX3 and mostly focused on recent findings of the pleiotropic activities played by PTX3 in the pathogenesis of autoimmune diseases, aiming at hopefully offering possible future therapeutic alternatives.
引用
收藏
页数：10
相关论文
共 140 条
  • [1] Adrovic A, 2017, CLIN EXP RHEUMATOL, V35, pS221
  • [2] Increased peripheral benzodiazepine binding sites and pentraxin 3 expression in the spinal cord during EAE: relation to inflammatory cytokines and modulation by dexamethasone and rolipram
    Agnello, D
    Carvelli, L
    Muzio, V
    Villa, P
    Bottazzi, B
    Polentarutti, N
    Mennini, T
    Mantovani, A
    Ghezzi, P
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2000, 109 (02) : 105 - 111
  • [3] ALLES VV, 1994, BLOOD, V84, P3483
  • [4] PROMOTER STRUCTURE AND TRANSCRIPTIONAL ACTIVATION OF THE MURINE TSG-14 GENE ENCODING A TUMOR-NECROSIS-FACTOR INTERLEUKIN-1-INDUCIBLE PENTRAXIN PROTEIN
    ALTMEYER, A
    KLAMPFER, L
    GOODMAN, AR
    VILCEK, J
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (43) : 25584 - 25590
  • [5] Common mechanisms of autoimmune diseases (the autoimmune tautology)
    Anaya, Juan-Manuel
    [J]. AUTOIMMUNITY REVIEWS, 2012, 11 (11) : 781 - 784
  • [6] [Anonymous], 2003, EUR J IMMUNOL, V33, P465
  • [7] Pentraxin 3 is useful to differentiate infections from flares in patients with systemic lupus erythematosus who present systemic inflammatory response
    Aragon, C. C.
    Nieto-Aristizabal, I.
    Rios-Serna, L. J.
    Barrera, M. C.
    Naranjo-Escobar, J.
    Posso-Osorio, I.
    Lara-Erazo, V.
    Leib, P.
    Moreno-Angarita, A.
    Aguirre-Valencia, D.
    Echeverri, A.
    Canas, C. A.
    Tobon, G. J.
    [J]. LUPUS, 2019, 28 (10) : 1279 - 1280
  • [8] Plasma pentraxin 3 is associated with progression of radiographic joint damage, but not carotid atherosclerosis, in female rheumatoid arthritis patients: 3-year prospective study
    Asanuma, Yu Funakubo
    Aizaki, Yoshimi
    Noma, Hisashi
    Yokota, Kazuhiro
    Matsuda, Mayumi
    Kozu, Noritsune
    Takebayashi, Yoshitake
    Nakatani, Hiroshi
    Hasunuma, Tomoko
    Kawai, Shinichi
    Mimura, Toshihide
    [J]. MODERN RHEUMATOLOGY, 2020, 30 (06) : 959 - 966
  • [9] Interactions between Trichinella spiralis infection and induced colitis in mice
    Ashour, D. S.
    Othman, A. A.
    Shareef, M. M.
    Gaballah, H. H.
    Mayah, W. W.
    [J]. JOURNAL OF HELMINTHOLOGY, 2014, 88 (02) : 210 - 218
  • [10] Pentraxin 3 Plasma Levels and Disease Activity in Systemic Lupus Erythematosus
    Assandri, Roberto
    Monari, Marta
    Colombo, Anna
    Dossi, Alessandra
    Montanelli, Alessandro
    [J]. AUTOIMMUNE DISEASES, 2015, 2015
12345678910