Lessons from an Aggressive Cancer: Evolutionary Dynamics in Esophageal Carcinoma

被引：41

作者：

Klein, Christoph A. ^{[1
]}

Stoecklein, Nikolas H. ^{[2
,3
]}

机构：

[1] Univ Regensburg, Dept Pathol, Div Oncogenom, D-93053 Regensburg, Germany

[2] Univ Dusseldorf, Dept Gen Visceral & Pediat Surg, Dusseldorf, Germany

[3] Univ Hosp, Dusseldorf, Germany

来源：

CANCER RESEARCH | 2009年 / 69卷 / 13期

关键词：

BONE-MARROW MICROMETASTASES; LYMPH-NODE MICROMETASTASIS; DISSEMINATED TUMOR-CELLS; PROGNOSTIC VALUE; ESOPHAGOGASTRIC JUNCTION; ADENOCARCINOMA; METASTASES; CHEMORADIOTHERAPY; PROGRESSION; THERAPY;

D O I：

10.1158/0008-5472.CAN-08-4586

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Rapid progression to metastatic disease and an intrinsic resistance to any type of systemic therapy are hallmarks of aggressive solid cancers. The molecular basis for this phenotype is not clear. A detailed study of the somatic progression from local to early systemic esophageal cancer revealed rapid diversification of cancer cells isolated from various sites, but also evidence for early clonal expansion. These findings have implications for diagnostic pathology and therapeutic decision making. [Cancer Res 2009;69(13):5285-8]

引用

页码：5285 / 5288

页数：4

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