The clinical value of dynamic contrast-enhanced magnetic resonance imaging at 3.0T to detect prostate cancer

被引：9
作者：
Zhang, Xuhui [1 ]
Quan, Xianyue [1 ]
Lu, Shilong [1 ]
Huang, Fanheng [1 ]
Yang, Jianming [1 ]
Chan, Queenie [2 ]
Lin, Ting [1 ]
机构：
[1] Southern Med Univ, Dept Radiol, Zhujiang Hosp, Guangzhou 510282, Guangdong, Peoples R China
[2] Philips Healthcare, Hong Kong, Hong Kong, Peoples R China
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2014年 / 42卷 / 05期
关键词：
Prostate cancer; T2WI; DCE-MRI; Gleason score; 3; T; MRI; LOCALIZATION;
D O I：
10.1177/0300060514541827
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objective: To compare dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and T-2-weighted imaging (T2WI) at 3.0T for detection of prostate cancer. Methods: Patients with elevated prostate-specific antigen underwent T2WI and DCE-MRI prior to prostate needle biopsy. The sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of T2WI and DCE-MRI to diagnose prostate cancer were evaluated. The relationship between Gleason score and prostate cancer detection by DCE-MRI was evaluated. Results: Prostate adenocarcinoma was histopathologically confirmed in 44/75 patients. DCE-MRI had significantly higher sensitivity, accuracy and NPV than T2WI. The detection rate of prostate cancer by DCE-MRI was significantly better for tumours with Gleason score 7-9 than for those Gleason score 4-6. Conclusion: DCE-MRI at 3.0T can significantly improve prostate cancer detection using simple visual diagnostic criteria, compared with T2WI.
引用
收藏
页码：1077 / 1084
页数：8
相关论文
共 30 条
[11]   Histological characteristics of the index lesion in whole-mount radical prostatectomy specimens: implications for focal therapy [J].
Karavitakis, M. ;
Winkler, M. ;
Abel, P. ;
Livni, N. ;
Beckley, I. ;
Ahmed, H. U. .
PROSTATE CANCER AND PROSTATIC DISEASES, 2011, 14 (01) :46-52
[12]   Simple models improve the discrimination of prostate cancers from the peripheral gland by T1-weighted dynamic MRI [J].
Kiessling, F ;
Lichy, M ;
Grobholz, R ;
Heilmann, M ;
Farhan, N ;
Michel, MS ;
Trojan, L ;
Ederle, J ;
Abel, U ;
Kauczor, HU ;
Semmler, W ;
Delorme, S .
EUROPEAN RADIOLOGY, 2004, 14 (10) :1793-1801
[13]   Update of prostate magnetic resonance imaging at 3 T [J].
Kim, Chan Kyo ;
Park, Byung Kwan .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 2008, 32 (02) :163-172
[14]   Prostate Cancer Detection With 3 T MRI: Comparison of Diffusion-Weighted Imaging and Dynamic Contrast-Enhanced MRI in Combination With T2-Weighted Imaging [J].
Kitajima, Kazuhiro ;
Kaji, Yasushi ;
Fukabori, Yoshitatsu ;
Yoshida, Ken-ichiro ;
Suganuma, Narufumi ;
Sugimura, Kazuro .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2010, 31 (03) :625-631
[15]   Analysis of Prostate DCE-MRI Comparison of Fast Exchange Limit and Fast Exchange Regimen Pharmacokinetic Models in the Discrimination of Malignant From Normal Tissue [J].
Lowry, Martin ;
Zelhof, Bashar ;
Liney, Gary P. ;
Gibbs, Peter ;
Pickles, Martin D. ;
Turnbull, Lindsay W. .
INVESTIGATIVE RADIOLOGY, 2009, 44 (09) :577-584
[16]   Dynamic contrast enhanced MRI of prostate cancer: Correlation with morphology and tumour stage, histological grade and PSA [J].
Padhani, AR ;
Gapinski, CJ ;
Macvicar, DA ;
Parker, GJ ;
Suckling, J ;
Revell, PB ;
Leach, MO ;
Dearnaley, DP ;
Husband, JE .
CLINICAL RADIOLOGY, 2000, 55 (02) :99-109
[17]   Effects of Post Biopsy Digital Rectal Compression on Improving Prostate Cancer Staging Using Magnetic Resonance Imaging in Localized Prostate Cancer [J].
Park, Kyung Kgi ;
Chung, Mun Su ;
Chung, Soo Yoon ;
Kim, Joo Hee ;
Chung, Byung Ha .
YONSEI MEDICAL JOURNAL, 2013, 54 (01) :81-86
[18]   Combined magnetic resonance spectroscopy and dynamic contrast-enhanced imaging for prostate cancer detection [J].
Perdona, Sisto ;
Di Lorenzo, Giuseppe ;
Autorino, Riccardo ;
Buonerba, Carlo ;
De Sio, Marco ;
Setola, Sergio Venanzio ;
Fusco, Roberta ;
Ronza, Francesco Michele ;
Caraglia, Michele ;
Ferro, Matteo ;
Petrillo, Antonella .
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2013, 31 (06) :761-765
[19]   Focal prostatic atrophy: mimicry of prostatic cancer on TRUS and 3D-MRSI studies [J].
Prando, Adilson ;
Billis, Athanase .
ABDOMINAL IMAGING, 2009, 34 (02) :271-275
[20]   Enhancement patterns of prostate cancer in dynamic MRI [J].
Preziosi, P ;
Orlacchio, A ;
Di Giambattista, G ;
Di Renzi, P ;
Bortolotti, L ;
Fabiano, A ;
Cruciani, E ;
Pasqualetti, P .
EUROPEAN RADIOLOGY, 2003, 13 (05) :925-930
123