Synthesis and characterization of dual-stimuli-responsive micelles based on poly(N-isopropylacrylamide) and polycarbonate with photocleavable moieties

被引：10

作者：

Fang, Jia-You ^{[1
]}

Lin, Yin-Ku ^{[2
]}

Wang, Shiu-Wei ^{[3
]}

Li, You-Chen ^{[3
]}

Lee, Ren-Shen ^{[3
]}

机构：

[1] Chang Gung Univ, Grad Inst Nat Prod, Taoyuan 333, Taiwan

[2] Chang Gung Mem Hosp, Dept Tradit Chinese Med, Keelung, Taiwan

[3] Chang Gung Univ, Ctr Gen Educ, Div Nat Sci, Taoyuan 333, Taiwan

来源：

REACTIVE & FUNCTIONAL POLYMERS | 2015年 / 95卷

关键词：

Thermo-sensitive; Photocleavable; Poly(N-isopropylamide); Polycarbonate; Micelle; BLOCK-COPOLYMER MICELLES; CONTROLLED DELIVERY; CONTROLLED-RELEASE; POLYMER; NANOPARTICLES; PH; BIOMATERIALS; DISSOCIATION; DOXORUBICIN; GLYCOL);

D O I：

10.1016/j.reactfunctpolym.2015.08.009

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Dual-sensitive block copolymers, PNiPAAm-b-PNBTMC, were synthesized via the ring-opening polymerization of 3-methyl-3-nitrobenzyl-trimethylene carbonate (NBTMC) bearing numerous 2-nitro-benzoxycarbonyl photolabile groups with a PNiPAAm macroinitiator in the presence of an organocatalyst, 1,5,7-triazobicyclo-[4.4.0]dec-5-ene (TBD). When the polymer solutions were exposed to ultraviolet (UV) irradiation, we observed significant changes in the structure and morphology of the particles. Fluorescence spectroscopy studies revealed that the copolymers underwent micellization or dissociation transitions in water in response to temperature changes and UV irradiation. No significant toxicity of these nanoparticles was found at concentrations up to 300 mu g mL(-1). (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：46 / 54

页数：9

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