Synthesis and characterization of dual-stimuli-responsive micelles based on poly(N-isopropylacrylamide) and polycarbonate with photocleavable moieties

被引：10
作者：
Fang, Jia-You [1 ]
Lin, Yin-Ku [2 ]
Wang, Shiu-Wei [3 ]
Li, You-Chen [3 ]
Lee, Ren-Shen [3 ]
机构：
[1] Chang Gung Univ, Grad Inst Nat Prod, Taoyuan 333, Taiwan
[2] Chang Gung Mem Hosp, Dept Tradit Chinese Med, Keelung, Taiwan
[3] Chang Gung Univ, Ctr Gen Educ, Div Nat Sci, Taoyuan 333, Taiwan
来源：
REACTIVE & FUNCTIONAL POLYMERS | 2015年 / 95卷
关键词：
Thermo-sensitive; Photocleavable; Poly(N-isopropylamide); Polycarbonate; Micelle; BLOCK-COPOLYMER MICELLES; CONTROLLED DELIVERY; CONTROLLED-RELEASE; POLYMER; NANOPARTICLES; PH; BIOMATERIALS; DISSOCIATION; DOXORUBICIN; GLYCOL);
D O I：
10.1016/j.reactfunctpolym.2015.08.009
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Dual-sensitive block copolymers, PNiPAAm-b-PNBTMC, were synthesized via the ring-opening polymerization of 3-methyl-3-nitrobenzyl-trimethylene carbonate (NBTMC) bearing numerous 2-nitro-benzoxycarbonyl photolabile groups with a PNiPAAm macroinitiator in the presence of an organocatalyst, 1,5,7-triazobicyclo-[4.4.0]dec-5-ene (TBD). When the polymer solutions were exposed to ultraviolet (UV) irradiation, we observed significant changes in the structure and morphology of the particles. Fluorescence spectroscopy studies revealed that the copolymers underwent micellization or dissociation transitions in water in response to temperature changes and UV irradiation. No significant toxicity of these nanoparticles was found at concentrations up to 300 mu g mL(-1). (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：46 / 54
页数：9
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  • [1] Photocontrolled Nanoparticles for On-Demand Release of Proteins
    Azagarsamy, Malar A.
    Alge, Daniel L.
    Radhakrishnan, Srinidhi J.
    Tibbitt, Mark W.
    Anseth, Kristi S.
    [J]. BIOMACROMOLECULES, 2012, 13 (08) : 2219 - 2224
  • [2] Dual thermo- and photo-responsive micelles based on miktoarm star polymers
    Blasco, Eva
    Schmidt, Bernhard V. K. J.
    Barner-Kowollik, Christopher
    Pinol, Milagros
    Oriol, Luis
    [J]. POLYMER CHEMISTRY, 2013, 4 (16) : 4506 - 4514
  • [3] Flower micelles of poly(N-isopropylacrylamide) with azobenzene moieties regularly inserted into the main chain
    Boissiere, Olivier
    Han, Dehui
    Tremblay, Luc
    Zhao, Yue
    [J]. SOFT MATTER, 2011, 7 (19) : 9410 - 9415
  • [4] pH and Reduction Dual-Sensitive Copolymeric Micelles for Intracellular Doxorubicin Delivery
    Chen, Jun
    Qiu, Xiaozhong
    Ouyang, Jun
    Kong, Jiming
    Zhong, Wen
    Xing, Malcolm M. Q.
    [J]. BIOMACROMOLECULES, 2011, 12 (10) : 3601 - 3611
  • [5] Light-Triggered Multifunctionality at Surfaces Mediated by Photolabile Protecting Groups
    Cui, Jiaxi
    San Miguel, Veronica
    del Campo, Aranzazu
    [J]. MACROMOLECULAR RAPID COMMUNICATIONS, 2013, 34 (04) : 310 - 329
  • [6] Methoxy poly(ethylene glycol)-poly(lactide) (MPEG-PLA) nanoparticles for controlled delivery of anticancer drugs
    Dong, YC
    Feng, SS
    [J]. BIOMATERIALS, 2004, 25 (14) : 2843 - 2849
  • [7] Organocatalytic Synthesis of Quinine-Functionalized Poly(carbonate)s
    Edward, Justin A.
    Kiesewetter, Matthew K.
    Kim, Hyunuk
    Flanagan, James C. A.
    Hedrick, James L.
    Waymouth, Robert M.
    [J]. BIOMACROMOLECULES, 2012, 13 (08) : 2483 - 2489
  • [8] Smart Nanocontainers: Progress on Novel Stimuli-Responsive Polymer Vesicles
    Feng, Anchao
    Yuan, Jinying
    [J]. MACROMOLECULAR RAPID COMMUNICATIONS, 2014, 35 (08) : 767 - 779
  • [9] Polymer Nanoparticles Based on PyreneFunctionalized Poly( acrylic acid) for Controlled Release under Photo and pH Stimulation
    Feng, Ning
    Dong, Jie
    Han, Guoxiang
    Wang, Guojie
    [J]. MACROMOLECULAR RAPID COMMUNICATIONS, 2014, 35 (07) : 721 - 726
  • [10] Dual Responsive Block Copolymer Micelles Functionalized by NIPAM and Azobenzene
    Feng, Ze
    Lin, Li
    Yan, Zeng
    Yu, Yanlei
    [J]. MACROMOLECULAR RAPID COMMUNICATIONS, 2010, 31 (07) : 640 - 644
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