The profile of executive function in OCD hoarders and hoarding disorder

被引:63
作者
Morein-Zamir, Sharon [1 ,2 ,3 ]
Papmeyer, Martina [1 ,3 ]
Pertusa, Alberto [4 ,5 ]
Chamberlain, Samuel R. [1 ,2 ]
Fineberg, Naomi A. [6 ]
Sahakian, Barbara J. [1 ,2 ]
Mataix-Cols, David [3 ,4 ,5 ]
Robbins, Trevor W. [1 ,3 ]
机构
[1] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge CB2 2QQ, England
[2] Univ Cambridge, Dept Psychiat, Cambridge CB2 2QQ, England
[3] Univ Cambridge, Dept Psychol, Cambridge CB2 2QQ, England
[4] Kings Coll London, Inst Psychiat, Dept Psychol, London WC2R 2LS, England
[5] Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London WC2R 2LS, England
[6] QEII Hosp, Mental Hlth Unit, Welwyn Garden City, Herts, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
Hoarding; Obsessive compulsive disorder (OCD); Cognition; Hoarding disorder; OBSESSIVE-COMPULSIVE DISORDER; DECISION-MAKING; COGNITIVE FLEXIBILITY; STRIATAL DYSFUNCTION; SYMPTOM DIMENSIONS; NEURAL MECHANISMS; MOTOR INHIBITION; LOBE LESIONS; DEFICITS; PERFORMANCE;
D O I
10.1016/j.psychres.2013.12.026
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Hoarding disorder is a new mental disorder in DSM-5. It is classified alongside OCD and other presumably related disorders in the Obsessive-Compulsive and Related Disorders chapter. We examined cognitive performance in two distinct groups comprising individuals with both OCD and severe hoarding, and individuals with hoarding disorder without comorbid OCD. Participants completed executive function tasks assessing inhibitory control, cognitive flexibility, spatial planning, probabilistic learning and reversal and decision making..Compared to a matched healthy control group, OCD hoarders showed significantly worse performance on measures of response inhibition, set shifting, spatial planning, probabilistic learning and reversal, with intact decision making. Despite having a strikingly different clinical presentation, individuals with only hoarding disorder did not differ significantly from OCD hoarders on any cognitive measure suggesting the two hoarding groups have a similar pattern of cognitive difficulties. Tests of cognitive flexibility were least similar across the groups, but differences were small and potentially reflected subtle variation in underlying brain pathology together with psychometric limitations. These results highlight both commonalities and potential differences between OCD and hoarding disorder, and together with other lines of evidence, support the inclusion of the new disorder within the new Obsessive-Compulsive and Related Disorders chapter in DSM-5. (C) 2013 The Authors. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:659 / 667
页数:9
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