Advances in Cardiac Tissue Engineering

被引：6

作者：

Kitsuka, Takahiro ^{[1
]}

Takahashi, Fuga ^{[1
]}

Reinhardt, James ^{[1
]}

Watanabe, Tatsuya ^{[1
]}

Ulziibayar, Anudari ^{[1
]}

Yimit, Asigul ^{[1
]}

Kelly, John ^{[1
]}

Shinoka, Toshiharu ^{[1
,2
,3
]}

机构：

[1] Nationwide Childrens Hosp, Ctr Regenerat Med, Columbus, OH 43205 USA

[2] Nationwide Childrens Hosp, Dept Cardiothorac Surg, Columbus, OH 43205 USA

[3] Ohio State Univ, Wexner Med Ctr, Dept Surg, Columbus, OH 43210 USA

来源：

BIOENGINEERING-BASEL | 2022年 / 9卷 / 11期

关键词：

tissue engineering; iPS-derived cardiac myocyte; biodegradable scaffolds; synthetic polymers; 3D culture; vascularization; 2D culture; 3D printing; clinical trials;

D O I：

10.3390/bioengineering9110696

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Tissue engineering has paved the way for the development of artificial human cardiac muscle patches (hCMPs) and cardiac tissue analogs, especially for treating Myocardial infarction (MI), often by increasing its regenerative abilities. Low engraftment rates, insufficient clinical application scalability, and the creation of a functional vascular system remain obstacles to hCMP implementation in clinical settings. This paper will address some of these challenges, present a broad variety of heart cell types and sources that can be applied to hCMP biomanufacturing, and describe some new innovative methods for engineering such treatments. It is also important to note the injection/transplantation of cells in cardiac tissue engineering.

引用

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