The pro-inflammatory-anti-inflammatory signaling balance is required for successful host-fungus interactions. The occurrence and interference of regulatory T (T-reg) cells in fungal infections offers a valuable framework for events that occur at the host-fungus interface. Control of both the class and magnitude of the immune response might confer an evolutionary advantage whereby the host effectively fights infection but limits collateral immunopathology. Alternatively, fungus-induced immunosuppression could be a powerful immunoevasion strategy for the invading pathogen. Discovery of T-reg cells as a source of IL-10 might contribute to a better understanding of the opposing functions and variable levels of production of this prototypic immunoregulatory cytokine in fungal infections and inflammatory diseases. T-reg cells, however, might also represent an additional mechanistic level at which host responses are subverted by fungi.
机构:Australian Natl Univ, John Curtin Sch Med Res, Med Genome Ctr, ACRF Genet Lab, Canberra, ACT 2601, Australia
Wilson, J
;
Peltonen, L
论文数: 0引用数: 0
h-index: 0
机构:Australian Natl Univ, John Curtin Sch Med Res, Med Genome Ctr, ACRF Genet Lab, Canberra, ACT 2601, Australia
Peltonen, L
;
Goodnow, CC
论文数: 0引用数: 0
h-index: 0
机构:
Australian Natl Univ, John Curtin Sch Med Res, Med Genome Ctr, ACRF Genet Lab, Canberra, ACT 2601, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Med Genome Ctr, ACRF Genet Lab, Canberra, ACT 2601, Australia
机构:Univ Michigan, Sch Med, Dept Internal Med, Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USA
Noverr, MC
;
Huffnagel, GB
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Internal Med, Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Internal Med, Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USA
机构:Australian Natl Univ, John Curtin Sch Med Res, Med Genome Ctr, ACRF Genet Lab, Canberra, ACT 2601, Australia
Wilson, J
;
Peltonen, L
论文数: 0引用数: 0
h-index: 0
机构:Australian Natl Univ, John Curtin Sch Med Res, Med Genome Ctr, ACRF Genet Lab, Canberra, ACT 2601, Australia
Peltonen, L
;
Goodnow, CC
论文数: 0引用数: 0
h-index: 0
机构:
Australian Natl Univ, John Curtin Sch Med Res, Med Genome Ctr, ACRF Genet Lab, Canberra, ACT 2601, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Med Genome Ctr, ACRF Genet Lab, Canberra, ACT 2601, Australia
机构:Univ Michigan, Sch Med, Dept Internal Med, Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USA
Noverr, MC
;
Huffnagel, GB
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Internal Med, Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Dept Internal Med, Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USA