Protective tolerance to fungi: the role of IL-10 and tryptophan catabolism

被引:114
作者
Romani, L [1 ]
Puccetti, P [1 ]
机构
[1] Univ Perugia, Microbiol Sect, Dept Expt Med & Biochem Sci, I-06126 Perugia, Italy
关键词
D O I
10.1016/j.tim.2006.02.003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The pro-inflammatory-anti-inflammatory signaling balance is required for successful host-fungus interactions. The occurrence and interference of regulatory T (T-reg) cells in fungal infections offers a valuable framework for events that occur at the host-fungus interface. Control of both the class and magnitude of the immune response might confer an evolutionary advantage whereby the host effectively fights infection but limits collateral immunopathology. Alternatively, fungus-induced immunosuppression could be a powerful immunoevasion strategy for the invading pathogen. Discovery of T-reg cells as a source of IL-10 might contribute to a better understanding of the opposing functions and variable levels of production of this prototypic immunoregulatory cytokine in fungal infections and inflammatory diseases. T-reg cells, however, might also represent an additional mechanistic level at which host responses are subverted by fungi.
引用
收藏
页码:183 / 189
页数:7
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