Beneficial effect of adjunctive azithromycin in treatment of mucoid Pseudomonas aeruginosa pneumonia in the murine model

被引:22
作者
Nicolau, DP
Banevicius, MA
Nightingale, CH
Quintiliani, R
机构
[1] Hartford Hosp, Dept Pharm Res, Hartford, CT 06102 USA
[2] Hartford Hosp, Div Infect Dis, Hartford, CT 06102 USA
[3] Hartford Hosp, Off Res Adm, Hartford, CT 06102 USA
关键词
D O I
10.1128/AAC.43.12.3033
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
While a time-kill methodology noted no appreciable improvement in bactericidal activity with the addition of azithromycin (AZM) to a ceftazidime (CAZ) regimen, data from the murine pneumonia model showed that the addition of AZM significantly improved survival compared to treatment with CAZ alone. These data suggest that AZM might be a useful adjunctive therapy in the management of pneumonia resulting from mucoid isolates of Pseudomonas aeruginosa.
引用
收藏
页码:3033 / 3035
页数:3
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