Effect of galanin(15-29)-related peptides on glucose-induced insulin release from the isolated perfused rat pancreas

被引：1

作者：

Kajiyama, F ^{[1
]}

Mukaiyama, S ^{[1
]}

Watanabe, Y ^{[1
]}

Ogata, M ^{[1
]}

Iguchi, K ^{[1
]}

Mochizuki, T ^{[1
]}

Hoshino, M ^{[1
]}

机构：

[1] Univ Shizuoka, Sch Pharmaceut Sci, Bioorgan Chem Lab, Shizuoka 4228526, Japan

来源：

BIOMEDICAL RESEARCH-TOKYO | 1999年 / 20卷 / 06期

关键词：

D O I：

10.2220/biomedres.20.345

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In the present study, we examined the effects of the C-terminal fragments and analogues of rat and porcine galanin on 13.9 mM glucose-induced insulin release from the isolated perfused rat pancreas. The results revealed clearly that [His(23), Tyr(26)]-rat galanin(15-29) and [His(23), Leu(29)]-rat galanin(15-29) at 10(-8) M as well as porcine galanin(15-29) exhibits insulinotropic activity on glucose-induced insulin release from the isolated perfused pancreas, whereas rat galanin(15-29) exhibited little effect on glucose-induced insulin release. The secondary structural analysis of the 15-29 sequence of rat and porcine galanins suggests that the conformation of the 15-29 sequences may be of importance for the insulinotropic activity of the C-terminal fragments.

引用

页码：345 / 351

页数：7

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