The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells

被引：30

作者：

Kang, Hoin ^{[1
]}

Rho, Jun Gi ^{[2
]}

Kim, Chongtae ^{[1
]}

Tak, Hyosun ^{[1
]}

Lee, Heejin ^{[1
]}

Ji, Eunbyul ^{[1
]}

Ahn, Sojin ^{[1
]}

Shin, A-Ri ^{[3
]}

Cho, Hyun-Il

Huh, Yun Hyun ^{[4
]}

Song, Woo Keun ^{[2
,4
]}

Kim, Wook ^{[2
]}

Lee, Eun Kyung ^{[1
,5
]}

机构：

[1] Catholic Univ Korea, Coll Med, Dept Biochem, Seoul, South Korea

[2] Ajou Univ, Dept Mol Sci & Technol, Suwon, South Korea

[3] Catholic Univ Korea, Coll Med, Catholic Canc Res Inst, Seoul, South Korea

[4] Gwangju Inst Sci & Technol, Bio Imaging & Cell Dynam Res Ctr, Dept Life Sci, Gwangju, South Korea

[5] Catholic Univ Korea, Canc Evolut Res Ctr, Seoul, South Korea

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

基金：

新加坡国家研究基金会;

关键词：

DOWN-REGULATION; P130CAS; PROLIFERATION; EXPRESSION; RESISTANCE; MICRORNAS; MECHANISM; CARCINOMA; APOPTOSIS; PROTEIN;

D O I：

10.1038/srep44847

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression by suppressing translation or facilitating mRNA decay. Differential expression of miRNAs is involved in the pathogenesis of several diseases including cancer. Here, we investigated the role of-miR-24-3p as a downregulated miRNA in metastatic cancer. miR-24-3p was decreased in metastatic cancer and lower expression of miR-24-3p was related to poor survival of cancer patients. Consistently, ectopic expression of miR-24-3p suppressed the cell migration, invasion, and proliferation of MCF7, Hep3B, B16F10, SK-Hep1, and PC-3 cells by directly targeting p130Cas. Stable expression of p130Cas restored miR-24-3p-mediated inhibition of cell migration and invasion. These results suggest that miR-24-3p functions as a tumor suppressor and the miR-24-3p/p130Cas axis is a novel factor of cancer progression by regulating cell migration and invasion.

引用

页数：10

共 50 条

[31] Dysregulation of Blimp1 transcriptional repressor unleashes p130Cas/ErbB2 breast cancer invasion
Sciortino, Marianna
Camacho-Leal, Maria del Pilar
Orso, Francesca
Grassi, Elena
Costamagna, Andrea
Provero, Paolo
Tam, Wayne
Turco, Emilia
Defilippi, Paola
Taverna, Daniela
Cabodi, Sara
SCIENTIFIC REPORTS, 2017, 7
[32] p130Cas induces bone invasion by oral squamous cell carcinoma by regulating tumor epithelial-mesenchymal transition and cell proliferation
Yaginuma, Tatsuki
Gao, Jing
Nagata, Kengo
Muroya, Ryusuke
Fei, Huang
Nagano, Haruki
Chishaki, Sakura
Matsubara, Takuma
Kokabu, Shoichiro
Matsuo, Kou
Kiyoshima, Tamotsu
Yoshioka, Izumi
Jimi, Eijiro
CARCINOGENESIS, 2020, 41 (08) : 1038 - 1048
[33] CircSTAM inhibits migration and invasion of trophoblast cells by regulating miR-148a-5p/PTEN axis
Chen, Lingfeng
Yan, Jinyu
Zhang, Haiyan
Xu, Jia
Chen, Xiaopei
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2023, 40 (01) : 201 - 210
[34] miR-17-5p promotes the invasion and migration of colorectal cancer by regulating HSPB2
Yu, Weifang
Wang, Jia
Li, Chao
Xuan, Mingda
Han, Shuangshuang
Zhang, Yingfu
Liu, Pengfei
Zhao, Zengren
JOURNAL OF CANCER, 2022, 13 (03): : 918 - 931
[35] miR-375-3p/YWHAZ/β-catenin axis regulates migration, invasion, EMT in gastric cancer cells
Guo, Feng
Gao, Yongjian
Sui, Guoqing
Jiao, Dan
Sun, Lina
Fu, Qingfeng
Jin, Chunxiang
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2019, 46 (02) : 144 - 152
[36] Methylation of the miR-29b-3p promoter contributes to angiogenesis, invasion, and migration in pancreatic cancer
Wang, Lihua
Mu, Nv
Qu, Nina
ONCOLOGY REPORTS, 2021, 45 (01) : 65 - 72
[37] miR-24-3p Is Overexpressed in Hodgkin Lymphoma and Protects Hodgkin and Reed-Sternberg Cells from Apoptosis
Yuan, Ye
Kluiver, Joost
Koerts, Jasper
de Jong, Debora
Rutgers, Bea
Razak, F. Reeny Abdul
Terpstra, Martijn
Plaat, Boudewijn E.
Nolte, Ilja M.
Diepstra, Arjan
Visser, Lydia
Kok, Klaas
van den Berg, Anke
AMERICAN JOURNAL OF PATHOLOGY, 2017, 187 (06) : 1343 - 1355
[38] miR-654-3p predicts the prognosis of hepatocellular carcinoma and inhibits the proliferation, migration, and invasion of cancer cells
Yang, Junsheng
Zhang, Zhen
Chen, Shaoping
Dou, Wenwen
Xie, Ruizhu
Gao, Jie
CANCER BIOMARKERS, 2020, 28 (01) : 73 - 79
[39] miR-24-3p and miR-27a-3p promote cell proliferation in glioma cells via cooperative regulation of MXI1
Xu, Weiyi
Liu, Mingfa
Peng, Xueling
Zhou, Peng
Zhou, Jianwen
Xu, Ke
Xu, Haixiong
Jiang, Songshan
INTERNATIONAL JOURNAL OF ONCOLOGY, 2013, 42 (02) : 757 - 766
[40] miR-182-5p affects human bladder cancer cell proliferation, migration and invasion through regulating Cofilin 1
Wang, Fei
Wu, Dinglan
Xu, Zhanping
Chen, Jianxiang
Zhang, Jiye
Li, Xiaojuan
Chen, Shiliang
He, Fengrong
Xu, Jianbing
Su, Liangju
Luo, Defan
Zhang, Shufang
Wang, Weifu
CANCER CELL INTERNATIONAL, 2019, 19 (1)

← 1 2 3 4 5 →