Relation between amino acid composition and cellular location of proteins

被引：348

作者：

Cedano, J

Aloy, P

PerezPons, JA

Querol, E

机构：

[1] UNIV AUTONOMA BARCELONA,INST BIOL FONAMENTAL 5,E-08193 BELLATERRA,BARCELONA,SPAIN

[2] UNIV AUTONOMA BARCELONA,DEPT BIOQUIM & BIOL MOL,E-08193 BELLATERRA,BARCELONA,SPAIN

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1997年 / 266卷 / 03期

关键词：

protein location; protein prediction algorithms; amino acid composition; protein sequence analysis; biocomputing;

D O I：

10.1006/jmbi.1996.0804

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A correlation analysis of the amino acid composition and the cellular location of a protein is presented. The statistical analysis discriminates among the following five protein classes: integral membrane proteins, anchored membrane proteins, extracellular proteins, intracellular proteins and nuclear proteins. This segregation into protein classes related to their location can help researchers to design experimental work for testing hypotheses in order to find out the functionality of a reading frame in search of function. A program (ProtLock) to predict the cellular location of a protein has been designed. (C) 1997 Academic Press Limited.

引用

页码：594 / 600

页数：7

共 27 条

[1]

ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999

[2]

BAYROCH A, 1992, NUCLEIC ACIDS RES, V20, P2013

[3]

BAYROCH A, 1992, NUCLEIC ACIDS RES, V20, P2019

[4] FROM GENOME SEQUENCES TO PROTEIN FUNCTION [J].

BORK, P ;

OUZOUNIS, C ;

SANDER, C .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1994, 4 (03) :393-403

[5] PROTEIN TRANSLOCATION AND TURNOVER IN EUKARYOTIC CELLS [J].

BRADSHAW, RA .

TRENDS IN BIOCHEMICAL SCIENCES, 1989, 14 (07) :276-279

[6] Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii [J].

Bult, CJ ;

White, O ;

Olsen, GJ ;

Zhou, LX ;

Fleischmann, RD ;

Sutton, GG ;

Blake, JA ;

FitzGerald, LM ;

Clayton, RA ;

Gocayne, JD ;

Kerlavage, AR ;

Dougherty, BA ;

Tomb, JF ;

Adams, MD ;

Reich, CI ;

Overbeek, R ;

Kirkness, EF ;

Weinstock, KG ;

Merrick, JM ;

Glodek, A ;

Scott, JL ;

Geoghagen, NSM ;

Weidman, JF ;

Fuhrmann, JL ;

Nguyen, D ;

Utterback, TR ;

Kelley, JM ;

Peterson, JD ;

Sadow, PW ;

Hanna, MC ;

Cotton, MD ;

Roberts, KM ;

Hurst, MA ;

Kaine, BP ;

Borodovsky, M ;

Klenk, HP ;

Fraser, CM ;

Smith, HO ;

Woese, CR ;

Venter, JC .

SCIENCE, 1996, 273 (5278) :1058-1073

[7] PREDICTION OF PROTEIN STRUCTURAL CLASSES [J].

CHOU, KC ;

ZHANG, CT .

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1995, 30 (04) :275-349

[8]

CLOTET J, 1994, COMPUT APPL BIOSCI, V10, P495

[9]

Fariselli P, 1996, COMPUT APPL BIOSCI, V12, P41

[10] WHOLE-GENOME RANDOM SEQUENCING AND ASSEMBLY OF HAEMOPHILUS-INFLUENZAE RD [J].

FLEISCHMANN, RD ;

ADAMS, MD ;

WHITE, O ;

CLAYTON, RA ;

KIRKNESS, EF ;

KERLAVAGE, AR ;

BULT, CJ ;

TOMB, JF ;

DOUGHERTY, BA ;

MERRICK, JM ;

MCKENNEY, K ;

SUTTON, G ;

FITZHUGH, W ;

FIELDS, C ;

GOCAYNE, JD ;

SCOTT, J ;

SHIRLEY, R ;

LIU, LI ;

GLODEK, A ;

KELLEY, JM ;

WEIDMAN, JF ;

PHILLIPS, CA ;

SPRIGGS, T ;

HEDBLOM, E ;

COTTON, MD ;

UTTERBACK, TR ;

HANNA, MC ;

NGUYEN, DT ;

SAUDEK, DM ;

BRANDON, RC ;

FINE, LD ;

FRITCHMAN, JL ;

FUHRMANN, JL ;

GEOGHAGEN, NSM ;

GNEHM, CL ;

MCDONALD, LA ;

SMALL, KV ;

FRASER, CM ;

SMITH, HO ;

VENTER, JC .

SCIENCE, 1995, 269 (5223) :496-512

← 1 2 3 →