Synthesis, Structural Characterization and Biological Activity of the Complex Diethyltin N-[(2-oxyphenyl)methylenelglycinates

被引：0

作者：

Tian Lai-Jin ^{[1
,2
]}

Yang Hong-Jun ^{[1
]}

Zheng Xiao-Liang ^{[3
]}

Sun Yu-Xi ^{[1
]}

Ni Zhong-Hai ^{[2
]}

Qian Bo-Chu ^{[3
]}

机构：

[1] Qufu Normal Univ, Dept Chem, Qufu 273165, Shandong, Peoples R China

[2] Shandong Univ, Dept Chem, Jinan 250100, Peoples R China

[3] Zhejiang Acad Med Sci, Inst Mat Med, Hangzhou 310013, Zhejiang, Peoples R China

来源：

CHINESE JOURNAL OF INORGANIC CHEMISTRY | 2009年 / 25卷 / 07期

关键词：

organotin carboxylate; glycine; in vitro antihimor activity; crystal structure; AMINO-ACIDS; X-RAY; DIORGANOTIN(IV) COMPLEXES; ANTITUMOR-ACTIVITY; MOIETIES; BONDS; NMR;

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Five new diethyltin N-[(2-oxyphenyl)methylene]glycinates,(CH3CH2)(2)Sn(2-O-3-X-5-YC6H2CH=NCH2, COO) (X, Y=H, H, 1; H, Cl, 2; H, Br, 3; Cl, Cl, 4; Br, Br, 5), have been prepared and characterized by elemental analysis, IR, H-1 and Sn-119 NMR spectra. The crystal structures of 1 and 4 have been determined. The crystal for 1 belongs to monoclinic space group P2(1), and the triclinic for 4 belongs to crystal space group P (1) over bar. The two compounds have a 12-membered macrocyclic structure with a trimeric [Sn3O6C3] core. Each tin atom is six-coordinated in distorted [SnC2NO3] octahedron geometry. Bioassay results show that the compound 5 has in vitro anti-tumor activity against three human tumour cell lines, HeLa, CoLo205 and MCF-7 and anti-bacterial activity against E. coli. CCDC: 729956, 1; 729957, 4.

引用

页码：1205 / 1211

页数：7

共 20 条

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