Hippocampal insulin resistance and cognitive dysfunction

被引：429

作者：

Biessels, Geert Jan ^{[1
]}

Reagan, Lawrence P. ^{[2
,3
]}

机构：

[1] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, NL-3508 GA Utrecht, Netherlands

[2] Univ S Carolina, Dept Pharmacol Physiol & Neurosci, Sch Med, Columbia, SC 29208 USA

[3] Wm Jennings Bryan Dorn Vet Affairs Med Ctr, Columbia, SC 29208 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2015年 / 16卷 / 11期

关键词：

HIGH-FAT-DIET; LONG-TERM POTENTIATION; BLOOD-BRAIN-BARRIER; OBESE ZUCKER RATS; TYPE-2; DIABETES-MELLITUS; HIGH SATURATED FAT; HIGH-ENERGY DIET; ALZHEIMERS-DISEASE; SYNAPTIC PLASTICITY; INTRANASAL INSULIN;

D O I：

10.1038/nrn4019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of the mechanisms underlying this relationship. Animal models of IR help to bridge these gaps and point to hippocampal IR as a potential mediator of cognitive dysfunction in T2DM, as well as in Alzheimer disease (AD). This Review highlights these observations and discusses intervention studies which suggest that the restoration of insulin activity in the hippocampus may be an effective strategy to alleviate the cognitive decline associated with T2DM and AD.

引用

页码：660 / 671

页数：12

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