An essential role for NF-kappa B in preventing TNF-alpha-induced cell death

被引：2793
作者：
Beg, AA [1 ]
Baltimore, D [1 ]
机构：
[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02139
来源：
SCIENCE | 1996年 / 274卷 / 5288期
关键词：
D O I：
10.1126/science.274.5288.782
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Studies on mice deficient in nuclear factor kappa B (NF-kappa B) subunits have shown that this transcription factor is important for lymphocyte responses to antigens and cylokine-inducible gene expression. In particular, the RelA (p65) subunit is required for induction of tumor necrosis factor-alpha (TNF-alpha)-dependent genes. Treatment of RelA-deficient (RelA(-/-)) mouse fibroblasts and macrophages with TNF-alpha resulted in a significant reduction in viability, whereas RelA(+/+) cells were unaffected. Cytotoxicity to both cell types was mediated by TNF receptor 1. Reintroduction of RelA into RelA(-/-) fibroblasts resulted in enhanced survival, demonstrating that the presence of RelA is required for protection from TNF-alpha. These results have implications for the treatment of inflammatory and proliferative diseases.
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收藏
页码：782 / 784
页数：3
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