Statins - Are they anticonvulsant?

被引：28
作者：
Banach, Monika [1 ]
Czuczwar, Stanislaw J. [2 ,3 ]
Borowicz, Kinga K. [1 ]
机构：
[1] Med Univ Lublin, Dept Pathophysiol, Expt Neuropathophysiol Unit, Lublin, Poland
[2] Med Univ Lublin, Dept Pathophysiol, Lublin, Poland
[3] Inst Rural Hlth, Dept Physiopathol, Lublin, Poland
来源：
PHARMACOLOGICAL REPORTS | 2014年 / 66卷 / 04期
关键词：
Statins; HMGCoA inhibitors; Epilepsy; Seizures; Neuroprotection; HIPPOCAMPAL CELL-DEATH; NITRIC-OXIDE; CORTICAL-NEURONS; INDUCED SEIZURES; INDUCED EXCITOTOXICITY; ATORVASTATIN TREATMENT; REDUCTASE INHIBITION; ANTIEPILEPTIC DRUGS; BRAIN CHOLESTEROL; LIPID RAFTS;
D O I：
10.1016/j.pharep.2014.02.026
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Statins are the most popular and effective lipid-lowering medications beneficial in hypercholesterolemias and prevention of cardiovascular diseases. Growing evidence supports theory that statins exhibit neuroprotective action in acute stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis or epilepsy. Hereby, we present available experimental data regarding action of this group of drugs on seizure activity and neuronal cell death. The most commonly examined statins, such as atorvastatin and simvastatin, display anticonvulsant action with only inconsiderable exceptions. However, the mechanism of this effect remains unexplained. Simvastatin, as a lipophilic statin, which can pass blood-brain barrier easily, was recommended as the best candidate for an anticonvulsant agent. Nevertheless, it is still indistinct, whether the protective activity of statins depends on cholesterol lowering properties or its pleiotropic characteristics. One of the most interesting of 3-hydroxy-3-methylglutaryl-coenzyme A inhibitor's actions involves influence on nitric oxide metabolism. (C) 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. Z o.o. All rights reserved.
引用
收藏
页码：521 / 528
页数：8
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