Determining the Causes and Consequences of Nicotine Dependence: Emerging Genetic Research Methods

被引:5
作者
Ware, Jennifer J. [1 ,2 ]
Munafo, Marcus R. [1 ,3 ,4 ]
机构
[1] Univ Bristol, MRC Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England
[2] Univ Bristol, Sch Social & Community Med, Bristol BS8 2BN, Avon, England
[3] Univ Bristol, UK Ctr Tobacco & Alcohol Studies, Bristol BS8 1TU, Avon, England
[4] Univ Bristol, Sch Expt Psychol, Bristol BS8 1TU, Avon, England
基金
英国医学研究理事会; 英国经济与社会研究理事会;
关键词
Nicotine; Tobacco; Smoking; Dependence; Genetics; GWAS; Mendelian randomisation; Recall-by-genotype; Phenotype refinement; Biomarkers; GENOME-WIDE METAANALYSES; SMOKING-BEHAVIOR; LUNG-CANCER; ASSOCIATION; VARIANTS; CLUSTER; 15Q25; METABOLISM; IMPUTATION; INTERACTS;
D O I
10.1007/s11920-014-0477-5
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Tobacco use remains the leading cause of preventable death worldwide. Establishing the genetic aetiology of tobacco use and dependence is an important first step in understanding the neurobiological mechanisms of tobacco use, and in turn the development of effective treatments. In addition, whilst the effects of tobacco use on a broad range of physical illnesses (e. g. lung cancer, respiratory disease, cardiovascular disease) are now well-established, the causal effects of tobacco use on a number of other outcomes remains to be established. Determining the causes and consequences of tobacco use therefore continues to be both a scientific and a public health priority. Herewe review emerging methods in genetic research that allow stronger causal inferences to be drawn from observational data.
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页数:6
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