Objective: Clinical stages in amyotrophic lateral sclerosis (ALS) can be measured using a simple system based on the number of CNS regions involved and requirement for gastrostomy or noninvasive ventilation (NIV). We aimed to design a standard operating procedure (SOP) to define the standardized use and application of the King's staging system. Methods: We designed a SOP for the King's staging system. We wrote case vignettes representative of ALS patients at different disease stages. During two workshops, we taught health care professionals how to use the SOP, then asked them to stage the vignettes using the SOP. We measured the extent to which SOP staging corresponded with correct clinical stage. Results: The reliability of staging using the SOP was excellent, with a Spearman's Rank coefficient of 0.95 (p<0.001), and was high for different groups of health care professionals, and for those with different levels of experience in ALS. The limits of agreement between SOP staging and actual clinical stage lie within a single stage, confirming that there is a clinically acceptable level of agreement between staging using the SOP and actual King's clinical stage. There were also no systematic biases of the SOP over the range of stages, either for over-staging or under-staging. Conclusions: We have demonstrated that the staging SOP provides a reliable method of calculating clinical stages in ALS patients and can be used prospectively by a range of health care professionals with different levels of experience, as for example may be the case in multicentre clinical trials.
机构:
Kings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, EnglandKings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, England
Fang, Ton
Al Khleifat, Ahmad
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Kings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, EnglandKings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, England
Al Khleifat, Ahmad
Meurgey, Jacques-Henri
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h-index: 0
机构:
Kings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, EnglandKings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, England
Meurgey, Jacques-Henri
Jones, Ashley
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h-index: 0
机构:
Kings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, EnglandKings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, England
Jones, Ashley
Leigh, P. Nigel
论文数: 0引用数: 0
h-index: 0
机构:
Brighton & Sussex Med Sch, Dept Neurol, Brighton, Sussex, EnglandKings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, England
Leigh, P. Nigel
Bensimon, Gilbert
论文数: 0引用数: 0
h-index: 0
机构:
Hop La Pitie Salpetriere, Dept Pharmacol, Paris, FranceKings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, England
Bensimon, Gilbert
Al-Chalabi, Ammar
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, England
Kings Coll Hosp London, Denmark Hill, London, EnglandKings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, England
机构:
Univ Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, ItalyUniv Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, Italy
Ferraro, D.
Consonni, D.
论文数: 0引用数: 0
h-index: 0
机构:
Fdn IRCCS Ca Granda Osped Maggiore Policlin, Epidemiol Unit, Milan, ItalyUniv Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, Italy
Consonni, D.
Fini, N.
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h-index: 0
机构:
Univ Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, ItalyUniv Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, Italy
Fini, N.
Fasano, A.
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h-index: 0
机构:
Univ Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, ItalyUniv Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, Italy
Fasano, A.
Del Giovane, C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Modena & Reggio Emilia, Dept Diagnost & Clin Med & Publ Hlth, Modena, ItalyUniv Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, Italy
Del Giovane, C.
Mandrioli, J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, ItalyUniv Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, Italy
机构:
Penn State Hlth, Milton S Hershey Med Ctr, Dept Neurol, Hershey, PA USATrinity Coll Dublin, Trin Biomed Sci Inst, Acad Unit Neurol, Room 5-41,Pearse St, Dublin 2, Ireland
Simmons, Zachary
van den Berg, Leonard H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Neurol, Utrecht, NetherlandsTrinity Coll Dublin, Trin Biomed Sci Inst, Acad Unit Neurol, Room 5-41,Pearse St, Dublin 2, Ireland
机构:
Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
Ling, Shuo-Chien
Polymenidou, Magdalini
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
Polymenidou, Magdalini
Cleveland, Don W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
机构:
Kings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, EnglandKings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, England
Fang, Ton
Al Khleifat, Ahmad
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, EnglandKings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, England
Al Khleifat, Ahmad
Meurgey, Jacques-Henri
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, EnglandKings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, England
Meurgey, Jacques-Henri
Jones, Ashley
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, EnglandKings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, England
Jones, Ashley
Leigh, P. Nigel
论文数: 0引用数: 0
h-index: 0
机构:
Brighton & Sussex Med Sch, Dept Neurol, Brighton, Sussex, EnglandKings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, England
Leigh, P. Nigel
Bensimon, Gilbert
论文数: 0引用数: 0
h-index: 0
机构:
Hop La Pitie Salpetriere, Dept Pharmacol, Paris, FranceKings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, England
Bensimon, Gilbert
Al-Chalabi, Ammar
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, England
Kings Coll Hosp London, Denmark Hill, London, EnglandKings Coll London, Maurice Wohl Clin Neurosci, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9RX, England
机构:
Univ Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, ItalyUniv Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, Italy
Ferraro, D.
Consonni, D.
论文数: 0引用数: 0
h-index: 0
机构:
Fdn IRCCS Ca Granda Osped Maggiore Policlin, Epidemiol Unit, Milan, ItalyUniv Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, Italy
Consonni, D.
Fini, N.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, ItalyUniv Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, Italy
Fini, N.
Fasano, A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, ItalyUniv Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, Italy
Fasano, A.
Del Giovane, C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Modena & Reggio Emilia, Dept Diagnost & Clin Med & Publ Hlth, Modena, ItalyUniv Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, Italy
Del Giovane, C.
Mandrioli, J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, ItalyUniv Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense, Dept Biomed Metab & Neurosci, Modena, Italy
机构:
Penn State Hlth, Milton S Hershey Med Ctr, Dept Neurol, Hershey, PA USATrinity Coll Dublin, Trin Biomed Sci Inst, Acad Unit Neurol, Room 5-41,Pearse St, Dublin 2, Ireland
Simmons, Zachary
van den Berg, Leonard H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Neurol, Utrecht, NetherlandsTrinity Coll Dublin, Trin Biomed Sci Inst, Acad Unit Neurol, Room 5-41,Pearse St, Dublin 2, Ireland
机构:
Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
Ling, Shuo-Chien
Polymenidou, Magdalini
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
Polymenidou, Magdalini
Cleveland, Don W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA