Levels of Maternal Serum Angiogenic Factors in Third-Trimester Normal Pregnancies: Reference Ranges, Influence of Maternal and Pregnancy Factors and Fetoplacental Doppler Indices

被引:8
作者
Martina Lobmaier, Silvia [1 ,2 ,3 ]
Figueras, Francesc [1 ,2 ]
Mercade, Imma [1 ,2 ]
Crovetto, Francesca [1 ,2 ]
Peguero, Anna [1 ,2 ]
Parra-Saavedra, Miguel [1 ,2 ]
Ortiz, Javier U. [1 ,2 ,3 ]
Crispi, Fatima [1 ,2 ]
Gratacos, Eduard [1 ,2 ]
机构
[1] Hosp Clin Barcelona, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Fetal i D Fetal Med Res Ctr, ES-08028 Barcelona, Spain
[2] Univ Barcelona, Ctr Biomed Res Rare Dis CIBER ER, IDIBAPS, Hosp St Joan de Deu, Barcelona, Spain
[3] Tech Univ Munich, Klinikum Rechts Isar, Frauenklin & Poliklin, D-80290 Munich, Germany
关键词
Placental growth factor; Soluble fms-like tyrosine kinase-1; Angiogenic factors; Normal value; Reference range; PLACENTAL GROWTH-FACTOR; UTERINE ARTERY DOPPLER; PULSATILITY INDEX; PREDICTIVE-VALUE; EARLY-ONSET; PREECLAMPSIA; RISK; 2ND-TRIMESTER; RESTRICTION; BLOOD;
D O I
10.1159/000360078
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Aim: To establish normal ranges of maternal placental growth factor (PIGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and sFlt-1/PIGF ratio at 32-41 weeks' gestation and to evaluate the influence of maternal characteristics, and of fetoplacental Doppler. Material and Methods: Serum levels of PIGF, sFlt-1 and sFlt-1/PIGF ratio were measured in 300 noncomplicated pregnancies (30 at each gestational week between 32 and 41). Quantile regression analysis was used to derive gestational age (GA)-adjusted normal ranges, and to account for characteristics that might influence serum levels. The relationship with Doppler indices was tested, including umbilical artery pulsatility index and middle cerebral artery pulsatility index. Results: PIGF decreased with GA from 32 weeks, while sFlt-1 and sFlt-1/PIGF ratio increased steadily. None of the factors evaluated showed any significant influence on the levels of angiogenic factors. PIGF multiple of the median significantly correlated with mean uterine artery Doppler (R -0.17; p = 0.029). Conclusions: In normal pregnancies during the third trimester, serum PIGF decreases, sFlt-1 increases and sFlt-1/PIGF ratio increases with GA. Angiogenic factor levels needed no adjustment for factors such as smoking, body mass index, blood pressure or parity. (C) 2014 S. Karger AG, Basel
引用
收藏
页码:38 / 43
页数:6
相关论文
共 33 条
  • [1] NORMAL VALUES OF PULSATILITY INDEX FROM FETAL VESSELS - A CROSS-SECTIONAL STUDY ON 1556 HEALTHY FETUSES
    ARDUINI, D
    RIZZO, G
    [J]. JOURNAL OF PERINATAL MEDICINE, 1990, 18 (03) : 165 - 172
  • [2] Second- and third-trimester serum levels of placental proteins in preeclampsia and small-for-gestational age pregnancies
    Bersinger, NA
    Odegård, RA
    [J]. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2004, 83 (01) : 37 - 45
  • [3] Angiogenic and Fibrinolytic Factors in Blood During the First Half of Pregnancy and Adverse Pregnancy Outcomes
    Coolman, Marianne
    Timmermans, Sarah
    de Groot, Christianne J. M.
    Russcher, Henk
    Lindemans, Jan
    Hofman, Albert
    Geurts-Moespot, Anneke J.
    Sweep, Fred C. G. J.
    Jaddoe, Vincent V. W.
    Steegers, Eric A. P.
    [J]. OBSTETRICS AND GYNECOLOGY, 2012, 119 (06) : 1190 - 1200
  • [4] Predictive value of angiogenic factors and uterine artery Doppler for early- versus late-onset pre-eclampsia and intrauterine growth restriction
    Crispi, F.
    Llurba, E.
    Dominguez, C.
    Martin-Gallan, P.
    Cabero, L.
    Gratacos, E.
    [J]. ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2008, 31 (03) : 303 - 309
  • [5] Placental angiogenic growth factors and uterine artery Doppler findings for characterization of different subsets in preeclampsia and in isolated intrauterine growth restriction
    Crispi, Fatima
    Dominguez, Carmen
    Llurba, Elisa
    Martin-Gallan, Pitar
    Cabero, Luis
    Gratacos, Eduard
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2006, 195 (01) : 201 - 207
  • [6] Maternal angiogenic profile in pregnancies that remain normotensive
    Faupel-Badger, Jessica M.
    Staff, Anne Cathrine
    Thadhani, Ravi
    Powe, Camille E.
    Potischman, Nancy
    Hoover, Robert N.
    Troisi, Rebecca
    [J]. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2011, 158 (02) : 189 - 193
  • [7] References intervals for fetal biometrical parameters
    Figueras, F
    Torrents, M
    Muñoz, A
    Comas, C
    Antolín, E
    Echevarría, M
    Mallafré, J
    Carrera, JM
    [J]. EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2002, 105 (01): : 25 - 30
  • [8] Disrupted Balance of Angiogenic and Antiangiogenic Signalings in Preeclampsia
    Furuya, Mitsuko
    Kurasawa, Kentaro
    Nagahama, Kiyotaka
    Kawachi, Kae
    Nozawa, Akinori
    Takahashi, Tsuneo
    Aoki, Ichiro
    [J]. JOURNAL OF PREGNANCY, 2011, 2011 : 123717
  • [9] Reference ranges for uterine artery mean pulsatility index at 11-41 weeks of gestation
    Gomez, O.
    Figueras, F.
    Fernandez, S.
    Bennasar, M.
    Martinez, J. M.
    Puerto, B.
    Gratacos, E.
    [J]. ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2008, 32 (02) : 128 - 132
  • [10] Cigarette smoke exposure and angiogenic factors in pregnancy and preeclampsia
    Jeyabalan, Arun
    Powers, Robert W.
    Durica, Allison R.
    Harger, Gail F.
    Roberts, James M.
    Ness, Roberta B.
    [J]. AMERICAN JOURNAL OF HYPERTENSION, 2008, 21 (08) : 943 - 947