Levels of Maternal Serum Angiogenic Factors in Third-Trimester Normal Pregnancies: Reference Ranges, Influence of Maternal and Pregnancy Factors and Fetoplacental Doppler Indices
被引:8
作者:
Martina Lobmaier, Silvia
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Hosp Clin Barcelona, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Fetal i D Fetal Med Res Ctr, ES-08028 Barcelona, Spain
Univ Barcelona, Ctr Biomed Res Rare Dis CIBER ER, IDIBAPS, Hosp St Joan de Deu, Barcelona, Spain
Tech Univ Munich, Klinikum Rechts Isar, Frauenklin & Poliklin, D-80290 Munich, GermanyHosp Clin Barcelona, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Fetal i D Fetal Med Res Ctr, ES-08028 Barcelona, Spain
Martina Lobmaier, Silvia
[1
,2
,3
]
Figueras, Francesc
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Hosp Clin Barcelona, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Fetal i D Fetal Med Res Ctr, ES-08028 Barcelona, Spain
Univ Barcelona, Ctr Biomed Res Rare Dis CIBER ER, IDIBAPS, Hosp St Joan de Deu, Barcelona, SpainHosp Clin Barcelona, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Fetal i D Fetal Med Res Ctr, ES-08028 Barcelona, Spain
Figueras, Francesc
[1
,2
]
Mercade, Imma
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Hosp Clin Barcelona, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Fetal i D Fetal Med Res Ctr, ES-08028 Barcelona, Spain
Univ Barcelona, Ctr Biomed Res Rare Dis CIBER ER, IDIBAPS, Hosp St Joan de Deu, Barcelona, SpainHosp Clin Barcelona, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Fetal i D Fetal Med Res Ctr, ES-08028 Barcelona, Spain
Mercade, Imma
[1
,2
]
Crovetto, Francesca
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Hosp Clin Barcelona, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Fetal i D Fetal Med Res Ctr, ES-08028 Barcelona, Spain
Univ Barcelona, Ctr Biomed Res Rare Dis CIBER ER, IDIBAPS, Hosp St Joan de Deu, Barcelona, SpainHosp Clin Barcelona, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Fetal i D Fetal Med Res Ctr, ES-08028 Barcelona, Spain
Crovetto, Francesca
[1
,2
]
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Peguero, Anna
[1
,2
]
Parra-Saavedra, Miguel
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机构:
Hosp Clin Barcelona, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Fetal i D Fetal Med Res Ctr, ES-08028 Barcelona, Spain
Univ Barcelona, Ctr Biomed Res Rare Dis CIBER ER, IDIBAPS, Hosp St Joan de Deu, Barcelona, SpainHosp Clin Barcelona, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Fetal i D Fetal Med Res Ctr, ES-08028 Barcelona, Spain
Parra-Saavedra, Miguel
[1
,2
]
Ortiz, Javier U.
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Hosp Clin Barcelona, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Fetal i D Fetal Med Res Ctr, ES-08028 Barcelona, Spain
Univ Barcelona, Ctr Biomed Res Rare Dis CIBER ER, IDIBAPS, Hosp St Joan de Deu, Barcelona, Spain
Tech Univ Munich, Klinikum Rechts Isar, Frauenklin & Poliklin, D-80290 Munich, GermanyHosp Clin Barcelona, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Fetal i D Fetal Med Res Ctr, ES-08028 Barcelona, Spain
Ortiz, Javier U.
[1
,2
,3
]
Crispi, Fatima
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Hosp Clin Barcelona, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Fetal i D Fetal Med Res Ctr, ES-08028 Barcelona, Spain
Univ Barcelona, Ctr Biomed Res Rare Dis CIBER ER, IDIBAPS, Hosp St Joan de Deu, Barcelona, SpainHosp Clin Barcelona, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Fetal i D Fetal Med Res Ctr, ES-08028 Barcelona, Spain
Crispi, Fatima
[1
,2
]
Gratacos, Eduard
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Hosp Clin Barcelona, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Fetal i D Fetal Med Res Ctr, ES-08028 Barcelona, Spain
Univ Barcelona, Ctr Biomed Res Rare Dis CIBER ER, IDIBAPS, Hosp St Joan de Deu, Barcelona, SpainHosp Clin Barcelona, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Fetal i D Fetal Med Res Ctr, ES-08028 Barcelona, Spain
Gratacos, Eduard
[1
,2
]
机构:
[1] Hosp Clin Barcelona, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Fetal i D Fetal Med Res Ctr, ES-08028 Barcelona, Spain
[2] Univ Barcelona, Ctr Biomed Res Rare Dis CIBER ER, IDIBAPS, Hosp St Joan de Deu, Barcelona, Spain
Aim: To establish normal ranges of maternal placental growth factor (PIGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and sFlt-1/PIGF ratio at 32-41 weeks' gestation and to evaluate the influence of maternal characteristics, and of fetoplacental Doppler. Material and Methods: Serum levels of PIGF, sFlt-1 and sFlt-1/PIGF ratio were measured in 300 noncomplicated pregnancies (30 at each gestational week between 32 and 41). Quantile regression analysis was used to derive gestational age (GA)-adjusted normal ranges, and to account for characteristics that might influence serum levels. The relationship with Doppler indices was tested, including umbilical artery pulsatility index and middle cerebral artery pulsatility index. Results: PIGF decreased with GA from 32 weeks, while sFlt-1 and sFlt-1/PIGF ratio increased steadily. None of the factors evaluated showed any significant influence on the levels of angiogenic factors. PIGF multiple of the median significantly correlated with mean uterine artery Doppler (R -0.17; p = 0.029). Conclusions: In normal pregnancies during the third trimester, serum PIGF decreases, sFlt-1 increases and sFlt-1/PIGF ratio increases with GA. Angiogenic factor levels needed no adjustment for factors such as smoking, body mass index, blood pressure or parity. (C) 2014 S. Karger AG, Basel
机构:
Univ Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Crispi, F.
Llurba, E.
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Univ Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Llurba, E.
Dominguez, C.
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Univ Autonoma Barcelona, Mol Biol & Biochem Res Ctr, Hosp Vall Hebron, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Dominguez, C.
Martin-Gallan, P.
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h-index: 0
机构:
Univ Autonoma Barcelona, Mol Biol & Biochem Res Ctr, Hosp Vall Hebron, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Martin-Gallan, P.
Cabero, L.
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机构:
Univ Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Cabero, L.
Gratacos, E.
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h-index: 0
机构:
Univ Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
机构:
Oslo Univ Hosp, Dept Obstet & Gynaecol, Ulleval, Norway
Univ Oslo, Fac Med, Oslo, NorwayNCI, Canc Prevent Fellowship Program, Ctr Canc Training, Rockville, MD USA
Staff, Anne Cathrine
Thadhani, Ravi
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h-index: 0
机构:
Massachusetts Gen Hosp, Boston, MA 02114 USA
Harvard Univ, Sch Med, Boston, MA USANCI, Canc Prevent Fellowship Program, Ctr Canc Training, Rockville, MD USA
Thadhani, Ravi
Powe, Camille E.
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机构:
Massachusetts Gen Hosp, Boston, MA 02114 USA
Harvard Univ, Sch Med, Boston, MA USANCI, Canc Prevent Fellowship Program, Ctr Canc Training, Rockville, MD USA
Powe, Camille E.
Potischman, Nancy
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h-index: 0
机构:
NCI, Appl Res Program, Div Canc Control & Populat Sci, Rockville, MD USANCI, Canc Prevent Fellowship Program, Ctr Canc Training, Rockville, MD USA
机构:
Yokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa 2360004, Japan
Furuya, Mitsuko
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Kurasawa, Kentaro
Nagahama, Kiyotaka
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Yokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa 2360004, Japan
Nagahama, Kiyotaka
Kawachi, Kae
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Yokohama City Univ, Med Ctr, Dept Pathol, Yokohama, Kanagawa 2320024, JapanYokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa 2360004, Japan
Kawachi, Kae
Nozawa, Akinori
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Yokohama City Univ, Med Ctr, Dept Pathol, Yokohama, Kanagawa 2320024, JapanYokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa 2360004, Japan
Nozawa, Akinori
Takahashi, Tsuneo
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Yokohama City Univ, Med Ctr, Dept Obstet, Yokohama, Kanagawa 2320024, JapanYokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa 2360004, Japan
Takahashi, Tsuneo
Aoki, Ichiro
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Yokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa 2360004, Japan
机构:
Magee Womens Res Inst & Fdn, Pittsburgh, PA USA
Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USAMagee Womens Res Inst & Fdn, Pittsburgh, PA USA
Jeyabalan, Arun
Powers, Robert W.
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机构:
Magee Womens Res Inst & Fdn, Pittsburgh, PA USA
Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USAMagee Womens Res Inst & Fdn, Pittsburgh, PA USA
Powers, Robert W.
Durica, Allison R.
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Magee Womens Res Inst & Fdn, Pittsburgh, PA USA
Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USAMagee Womens Res Inst & Fdn, Pittsburgh, PA USA
Durica, Allison R.
Harger, Gail F.
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Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USAMagee Womens Res Inst & Fdn, Pittsburgh, PA USA
Harger, Gail F.
Roberts, James M.
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Magee Womens Res Inst & Fdn, Pittsburgh, PA USA
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USAMagee Womens Res Inst & Fdn, Pittsburgh, PA USA
Roberts, James M.
Ness, Roberta B.
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h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USA
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USAMagee Womens Res Inst & Fdn, Pittsburgh, PA USA
机构:
Univ Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Crispi, F.
Llurba, E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Llurba, E.
Dominguez, C.
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h-index: 0
机构:
Univ Autonoma Barcelona, Mol Biol & Biochem Res Ctr, Hosp Vall Hebron, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Dominguez, C.
Martin-Gallan, P.
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机构:
Univ Autonoma Barcelona, Mol Biol & Biochem Res Ctr, Hosp Vall Hebron, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Martin-Gallan, P.
Cabero, L.
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h-index: 0
机构:
Univ Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
Cabero, L.
Gratacos, E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
CIBERER, Inst Salud Carlos III, Barcelona, SpainUniv Autonoma Barcelona, Dept Obstet, Dept Fetal Unit, E-08193 Barcelona, Spain
机构:
Oslo Univ Hosp, Dept Obstet & Gynaecol, Ulleval, Norway
Univ Oslo, Fac Med, Oslo, NorwayNCI, Canc Prevent Fellowship Program, Ctr Canc Training, Rockville, MD USA
Staff, Anne Cathrine
Thadhani, Ravi
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Boston, MA 02114 USA
Harvard Univ, Sch Med, Boston, MA USANCI, Canc Prevent Fellowship Program, Ctr Canc Training, Rockville, MD USA
Thadhani, Ravi
Powe, Camille E.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Boston, MA 02114 USA
Harvard Univ, Sch Med, Boston, MA USANCI, Canc Prevent Fellowship Program, Ctr Canc Training, Rockville, MD USA
Powe, Camille E.
Potischman, Nancy
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Appl Res Program, Div Canc Control & Populat Sci, Rockville, MD USANCI, Canc Prevent Fellowship Program, Ctr Canc Training, Rockville, MD USA
机构:
Yokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa 2360004, Japan
Furuya, Mitsuko
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h-index:
机构:
Kurasawa, Kentaro
Nagahama, Kiyotaka
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa 2360004, Japan
Nagahama, Kiyotaka
Kawachi, Kae
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Med Ctr, Dept Pathol, Yokohama, Kanagawa 2320024, JapanYokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa 2360004, Japan
Kawachi, Kae
Nozawa, Akinori
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Med Ctr, Dept Pathol, Yokohama, Kanagawa 2320024, JapanYokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa 2360004, Japan
Nozawa, Akinori
Takahashi, Tsuneo
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Med Ctr, Dept Obstet, Yokohama, Kanagawa 2320024, JapanYokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa 2360004, Japan
Takahashi, Tsuneo
Aoki, Ichiro
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa 2360004, Japan
机构:
Magee Womens Res Inst & Fdn, Pittsburgh, PA USA
Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USAMagee Womens Res Inst & Fdn, Pittsburgh, PA USA
Jeyabalan, Arun
Powers, Robert W.
论文数: 0引用数: 0
h-index: 0
机构:
Magee Womens Res Inst & Fdn, Pittsburgh, PA USA
Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USAMagee Womens Res Inst & Fdn, Pittsburgh, PA USA
Powers, Robert W.
Durica, Allison R.
论文数: 0引用数: 0
h-index: 0
机构:
Magee Womens Res Inst & Fdn, Pittsburgh, PA USA
Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USAMagee Womens Res Inst & Fdn, Pittsburgh, PA USA
Durica, Allison R.
Harger, Gail F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USAMagee Womens Res Inst & Fdn, Pittsburgh, PA USA
Harger, Gail F.
Roberts, James M.
论文数: 0引用数: 0
h-index: 0
机构:
Magee Womens Res Inst & Fdn, Pittsburgh, PA USA
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USAMagee Womens Res Inst & Fdn, Pittsburgh, PA USA
Roberts, James M.
Ness, Roberta B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USA
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USAMagee Womens Res Inst & Fdn, Pittsburgh, PA USA