Akathisia: prevalence and risk factors in a community-dwelling sample of patients with schizophrenia. Results from the FACE-SZ dataset

被引：37

作者：

Berna, F. ^{[1
]}

Misdrahi, D. ^{[1
,5
,6
,16
]}

Boyer, L. ^{[1
,4
]}

Aouizerate, B. ^{[1
,5
,6
,15
]}

Brunel, L. ^{[1
,2
,3
]}

Capdevielle, D. ^{[1
,8
]}

Chereau, I. ^{[1
,9
]}

Danion, J. M. ^{[1
,7
,10
]}

Dorey, J. M. ^{[1
]}

Dubertret, C. ^{[1
,11
]}

Dubreucq, J. ^{[1
,12
]}

Faget, C. ^{[1
,13
]}

Gabayet, F. ^{[1
,12
]}

Lancon, C. ^{[1
,13
]}

Mallet, J. ^{[1
,11
]}

Rey, R. ^{[1
,10
]}

Passerieux, C. ^{[1
,14
]}

Schandrin, A. ^{[1
,8
]}

Schurhoff, F. ^{[1
,2
,3
]}

Tronche, A. M. ^{[1
,9
]}

Urbach, M. ^{[1
,14
]}

Vidailhet, P. ^{[1
,7
]}

Llorca, P. M. ^{[1
,9
]}

Fond, G. ^{[1
,3
]}

机构：

[1] Fdn FondaMental, Creteil, France

[2] INSERM U955, Equipe Psychiat Translat, Creteil, France

[3] Univ Paris Est Creteil, DHU Pe PSY, Pole Psychiat Hop Univ H Mondor, Creteil, France

[4] CHU St Marguerite, Pole Psychiat Univ, F-13274 Marseille 09, France

[5] Ctr Hosp Charles Perrens, F-33076 Bordeaux, France

[6] Univ Bordeaux, Talence, France

[7] Univ Strasbourg, Hop Univ Strasbourg, INSERM U1114, Federat Med Translat Strasbourg, Strasbourg, France

[8] Univ Montpellier 1, CHRU Montpellier, Inserm 1061, Serv Univ Psychiat Adulte,Hop Colombiere, Montpellier, France

[9] Univ Auvergne, EA Fac Med 7280, CHU, CMP B, F-63003 Clermont Ferrand 1, France

[10] Univ Lyon 1, Ctr Hosp Le Vinatier, F-69678 Bron, France

[11] Univ Paris Diderot, Sorbonne Paris Cite, Louis Mourier Hosp, AP HP,Fac Med,Dept Psychiat,Inserm U894, Colombes, France

[12] CH Alpes Isere, Ctr Referent Rehabil Psychosociale, Grenoble, France

[13] Pole Univ Psychiat, AP HM, Marseille, France

[14] Univ Versailles St Quentin En Yvelines, UFR Sci St Simone Veil, Ctr Hosp Versailles, Serv Psychiat Adulte, Versailles, France

[15] INSERM, Neuroctr Magendie, Physiopathol Plasticite Neuronale, U862, F-33000 Bordeaux, France

[16] CNRS, UMR 5287, INCIA, F-75700 Paris, France

来源：

SCHIZOPHRENIA RESEARCH | 2015年 / 169卷 / 1-3期

关键词：

Schizophrenia; Akathisia; Antipsychotic; Antidepressant; Benzodiazepine; Anticholinergic drug; NEUROLEPTIC-INDUCED AKATHISIA; DRUG-INDUCED AKATHISIA; RATING-SCALE; CONVENTIONAL ANTIPSYCHOTICS; SCHIZOAFFECTIVE DISORDER; TARDIVE-DYSKINESIA; MOVEMENT-DISORDERS; POLYPHARMACY; POPULATION; MANAGEMENT;

D O I：

10.1016/j.schres.2015.10.040

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The main objective of this study was to determine the prevalence of akathisia in a community-dwelling sample of patients with schizophrenia, and to determine the effects of treatments and the clinical variables associated with akathisia. 372 patients with schizophrenia or schizoaffective disorder were systematically included in the network of FondaMental Expert Center for Schizophrenia and assessed with validated scales. Akathisia was measured with the Barnes Akathisia Scale (BAS). Ongoing psychotropic treatment was recorded. The global prevalence of akathisia (as defined by a score of 2 or more on the global akathisia subscale of the BAS) in our sample was 18.5%. Patients who received antipsychotic polytherapy were at higher risk of akathisia and this result remained significant (adjusted odd ratio =2.04, p=.025) after controlling the influence of age, gender, level of education, level of psychotic symptoms, substance use comorbidities, current administration of antidepressant, anticholinergic drugs, benzodiazepines, and daily-administered antipsychotic dose. The combination of second-generation antipsychotics was associated with a 3-fold risk of akathisia compared to second-generation antipsychotics used in monotherapy. Our results indicate that antipsychotic polytherapy should be at best avoided and suggest that monotherapy should be recommended in cases of akathisia. Long-term administration of benzodiazepines or anticholinergic drugs does not seem to be advisable in cases of akathisia, given the potential side effects of these medications. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：255 / 261

页数：7

共 48 条

[1]

[Anonymous], 2002, Cochrane Database Syst Rev, DOI DOI 10.1002/14651858.CD001950

[2]

[Anonymous], 2000, DIAGN STAT MAN MENT, DOI DOI 10.1176/APPI.BOOKS.9780890425787

[3] A RATING-SCALE FOR DRUG-INDUCED AKATHISIA [J].