Synthesis, characterization, DNA binding and cleavage properties of a ternary copper(II) Schiff base complex

被引：18
|
作者：
Li, Xin [1 ]
Bi, Cai-Feng [1 ]
Fan, Yu-Hua [1 ]
Zhang, Xia [1 ]
Wei, Xiao-Dan [1 ]
Meng, Xiang-Min [1 ]
机构：
[1] Ocean Univ China, Key Lab Marine Chem Theory & Technol, Minist Educ, Coll Chem & Chem Engn, Qingdao 266100, Shandong, Peoples R China
来源：
TRANSITION METAL CHEMISTRY | 2014年 / 39卷 / 05期
基金：
高等学校博士学科点专项科研基金; 中国国家自然科学基金;
关键词：
CALF THYMUS DNA; ANTIOXIDANT ACTIVITY; CRYSTAL-STRUCTURE; FLUORESCENCE; LIGANDS; PROBE; ACID;
D O I：
10.1007/s11243-014-9836-7
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A ternary coordination complex 2Cu(C14H8NO3Cl)(C12H8N2)center dot 3CH(3)OH of a Schiff base (C14H8NO3Cl: 4-chloroanthranilic acid-salicylaldehyde) was synthesized from 4-chloroanthranilic acid, salicylaldehyde, copper acetate and 1,10-phenanthroline and characterized by physicochemical and spectroscopic methods. X-ray crystallography shows that the copper atom is five coordinated by the imine nitrogen, two nitrogen atoms from 1,10-phenanthroline, the hydroxyl oxygen and the carboxylate oxygen atom. The interaction of the complex with calf-thymus DNA was investigated by UV absorption spectroscopy, fluorescence emission spectroscopy and viscosity. In addition, the cleavage reaction with pBR322 supercoiled plasmid DNA was investigated. The complex binds to DNA and also exhibits significant DNA cleavage activity.
引用
收藏
页码：577 / 584
页数：8
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