Aromatherapeutic essential oils and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofilm formation of human pathogens

被引：3
作者：
Ozfenerci, Mujgan [1 ,2 ]
Bali, Elif Burcu [3 ]
Erdonmez, Demet [4 ]
Caliskan, Ufuk Koca [1 ,2 ,5 ]
机构：
[1] Gazi Univ, Fac Pharm, Dept Pharmacognosy, Ankara, Turkey
[2] Gazi Univ, Fac Pharm, Phytotherapy Programme, Ankara, Turkey
[3] Gazi Univ, Vocat Sch Hlth Serv, Dept Med Serv & Tech, Programme Med Lab Tech, Ankara, Turkey
[4] Duzce Univ, Fac Pharm, Dept Pharmaceut Microbiol, Duzce, Turkey
[5] Duzce Univ, Fac Pharm, Dept Pharmacognosy, Duzce, Turkey
来源：
ISTANBUL JOURNAL OF PHARMACY | 2022年 / 52卷 / 01期
关键词：
Aromatherapeutic essential oils; Antibiofilm; Quorum sensing; Pseudomonas aeruginosa PA01; Synergistic effect; ANTI-BIOFILM; CHROMOBACTERIUM-VIOLACEUM; PSEUDOMONAS-AERUGINOSA; ANTIBACTERIAL; FLUORESCENS; ANTIOXIDANT; COMPONENTS;
D O I：
10.26650/IstanbulJPharm.2022.998774
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background and Aims: Aromatherapy, as one of the complementary therapies, uses essential oils as the main therapeutic agents to treat several diseases. In the present study, it was aimed to investigate inhibition of quorum sensing (QS) and biofilm formation of aromatherapeutic essential oils (AEOs) and their pharmaceutical combinations (PC-I and PC-II). Methods: The anti-QS potential of AEOs were determined using the biosensor strains Chromobacterium violaceum ATCC 12472 and Pseudomonas aeruginosa PA01. Anti-QS activity was detected by agar-well diffusion and violacein pigment inhibition assays. Blocking of PA01 swim and swarm motilities and biofilm formation was also performed. Results: Most of the AEOs demonstrated highly active (>95%) violacein pigment inhibition. Additionally, they inhibited swarming (40.34%-72.80%) and swimming (20.06%-50.08%) motilities of PA01. Moreover, the majority of AEOs also decreased the biofilm formation, particularly on P. aeruginosa and S. aureus. Conclusion: Consequently, aromatherapeutic formulations might be a complementary or prophylactic cure for infectious disease by their anti-OS and antibiofilm activities rather than just antimicrobial effects.
引用
收藏
页码：54 / 63
页数：10
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