Aromatherapeutic essential oils and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofilm formation of human pathogens

被引：3
作者：
Ozfenerci, Mujgan [1 ,2 ]
Bali, Elif Burcu [3 ]
Erdonmez, Demet [4 ]
Caliskan, Ufuk Koca [1 ,2 ,5 ]
机构：
[1] Gazi Univ, Fac Pharm, Dept Pharmacognosy, Ankara, Turkey
[2] Gazi Univ, Fac Pharm, Phytotherapy Programme, Ankara, Turkey
[3] Gazi Univ, Vocat Sch Hlth Serv, Dept Med Serv & Tech, Programme Med Lab Tech, Ankara, Turkey
[4] Duzce Univ, Fac Pharm, Dept Pharmaceut Microbiol, Duzce, Turkey
[5] Duzce Univ, Fac Pharm, Dept Pharmacognosy, Duzce, Turkey
来源：
ISTANBUL JOURNAL OF PHARMACY | 2022年 / 52卷 / 01期
关键词：
Aromatherapeutic essential oils; Antibiofilm; Quorum sensing; Pseudomonas aeruginosa PA01; Synergistic effect; ANTI-BIOFILM; CHROMOBACTERIUM-VIOLACEUM; PSEUDOMONAS-AERUGINOSA; ANTIBACTERIAL; FLUORESCENS; ANTIOXIDANT; COMPONENTS;
D O I：
10.26650/IstanbulJPharm.2022.998774
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background and Aims: Aromatherapy, as one of the complementary therapies, uses essential oils as the main therapeutic agents to treat several diseases. In the present study, it was aimed to investigate inhibition of quorum sensing (QS) and biofilm formation of aromatherapeutic essential oils (AEOs) and their pharmaceutical combinations (PC-I and PC-II). Methods: The anti-QS potential of AEOs were determined using the biosensor strains Chromobacterium violaceum ATCC 12472 and Pseudomonas aeruginosa PA01. Anti-QS activity was detected by agar-well diffusion and violacein pigment inhibition assays. Blocking of PA01 swim and swarm motilities and biofilm formation was also performed. Results: Most of the AEOs demonstrated highly active (>95%) violacein pigment inhibition. Additionally, they inhibited swarming (40.34%-72.80%) and swimming (20.06%-50.08%) motilities of PA01. Moreover, the majority of AEOs also decreased the biofilm formation, particularly on P. aeruginosa and S. aureus. Conclusion: Consequently, aromatherapeutic formulations might be a complementary or prophylactic cure for infectious disease by their anti-OS and antibiofilm activities rather than just antimicrobial effects.
引用
收藏
页码：54 / 63
页数：10
相关论文
共 50 条
[11]   Anti-quorum sensing activity of essential oils from Colombian plants [J].
Jaramillo-Colorado, Beatriz ;
Olivero-Verbel, Jesus ;
Stashenko, Elena E. ;
Wagner-Doebler, Irene ;
Kunze, Brigitte .
NATURAL PRODUCT RESEARCH, 2012, 26 (12) :1075-1086
[12]   Food-Grade Bacteria Combat Pathogens by Blocking AHL-Mediated Quorum Sensing and Biofilm Formation [J].
Savijoki, Kirsi ;
San-Martin-Galindo, Paola ;
Pitkaenen, Katriina ;
Edelmann, Minnamari ;
Sillanpaeae, Annika ;
van der Velde, Cim ;
Miettinen, Ilkka ;
Patel, Jayendra Z. ;
Yli-Kauhaluoma, Jari ;
Parikka, Mataleena ;
Fallarero, Adyary ;
Varmanen, Pekka .
FOODS, 2023, 12 (01)
[13]   Inhibition of quorum sensing-controlled biofilm formation in Pseudomonas aeruginosa by quorum-sensing inhibitors [J].
Kalaiarasan, Ellappan ;
Kottha, Thirumalaswamy ;
Harish, Belgode Narasimha ;
Gnanasambandam, Vasuki ;
Sali, Veeresh Kumar ;
John, James .
MICROBIAL PATHOGENESIS, 2017, 111 :99-107
[14]   Biofilm formation and inhibition mediated by bacterial quorum sensing [J].
Yingsong Wang ;
Zeran Bian ;
Yan Wang .
Applied Microbiology and Biotechnology, 2022, 106 :6365-6381
[15]   Coumarin: a novel player in microbial quorum sensing and biofilm formation inhibition [J].
F. Jerry Reen ;
José A. Gutiérrez-Barranquero ;
María L. Parages ;
Fergal O´Gara .
Applied Microbiology and Biotechnology, 2018, 102 :2063-2073
[16]   Inhibition of Quorum Sensing Mechanism and Aeromonas hydrophila Biofilm Formation by Vanillin [J].
Ponnusamy, Kannan ;
Paul, Diby ;
Kweon, Ji Hyang .
ENVIRONMENTAL ENGINEERING SCIENCE, 2009, 26 (08) :1359-1363
[17]   STREPTOCOCCUS PNEUMONIAE QUORUM SENSING AND BIOFILM FORMATION ARE AFFECTED BY THYMUS DAENENSIS, SATUREJA HORTENSIS, AND ORIGANUM VULGARE ESSENTIAL OILS [J].
Sharifi, Aram ;
Ahmadi, Ali ;
Mohammadzadeh, Abdolmajid .
ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 2018, 65 (03) :345-359
[18]   Evaluation of Antibacterial Activity in Some Algerian Essential Oils and Selection of Thymus vulgaris as a Potential Biofilm and Quorum Sensing Inhibitor Against Pseudomonas aeruginosa [J].
Aggad, Fatima Zahra Mohammed ;
Ilias, Faiza ;
Elghali, Fares ;
Mrabet, Rania ;
El Haci, Imad Abdelhamid ;
Aifa, Sami ;
Mnif, Sami .
CHEMISTRY & BIODIVERSITY, 2025, 22 (05)
[19]   Quorum quenching activity of pentacyclic triterpenoids leads to inhibition of biofilm formation by Acinetobacter baumannii [J].
Paul Bhattacharya, Sudipta ;
Mitra, Akash ;
Bhattacharya, Arijit ;
Sen, Aparna .
BIOFOULING, 2020, 36 (08) :922-937
[20]   Anti-oxidant, antibacterial, anti-biofilm, and anti-quorum sensing activities of four essential oils against multidrug-resistant bacterial clinical isolates [J].
Alibi, Sana ;
Ben Selma, Walid ;
Ramos-Vivas, Jose ;
Smach, Mohamed Ali ;
Touati, Ridha ;
Boukadida, Jalel ;
Navas, Jesus ;
Ben Mansour, Hedi .
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE, 2020, 68 (02) :59-66
12345