Cytotoxic constituents from Vicia monantha subsp. monantha seeds

被引：12

作者：

El-Halawany, Ali M. ^{[1
]}

Osman, Samir M. ^{[2
]}

Abdallah, Hossam M. ^{[1
]}

机构：

[1] Cairo Univ, Dept Pharmacognosy, Fac Pharm, Cairo, Egypt

[2] October 6 Univ, Dept Pharmacognosy, Fac Pharm, Cairo, Egypt

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 12期

关键词：

Anticancer; Vicia monantha subsp; monantha; colon cancer; breast cancer;

D O I：

10.1080/14786419.2018.1434638

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Chemical investigation of Vicia monantha subsp. monantha Retz. revealed isolation of one new hydroxy- fatty acid (6) identified as (6-Z, 10-E)-9-hydroxy henicosa-6,10-dienoic acid in addition to six known metabolites; hexadecanoic acid (1), beta-sitosterol (2), beta-amyrin (3), beta-sitosterol-glucoside (4), 2,3-dihydroxypropyl tetradecanoate (5) and (Z)-9-hydroxypentadec-6-enoic acid (7). The cytotoxic effect of the isolated compounds was assessed by MTT assay using lung cancer A-549, prostate cancer PC3, breast cancer MCF-7, colon cancer HCT-116 and liver cancer HepG2 cell lines. Only compounds 1, 2, and 4 showed cytotoxic effect on HCT-116 cells where compound 2 was the most active with IC50 value of 22.61 mu g/mL. In addition, compounds 1, 2, 3, and 4 showed promising cytotoxic effect on MCF-7 cells with IC50 values of 21.03, 15.42, 10.089, and 11.34 mu g/mL, respectively. [GRAPHICS] .

引用

页码：1783 / 1786

页数：4

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