Ginsenoside Rd mitigates myocardial ischemia-reperfusion injury via Nrf2/HO-1 signaling pathway

被引：4
|
作者：
Zeng, Xiaofeng [1 ]
Li, Juan [2 ]
Li, Zhen [1 ]
机构：
[1] Kunming Med Univ, Sch Forens Med, Kunming 650500, Yunnan, Peoples R China
[2] Ctr Dis Control & Prevent, Kunming, Yunnan, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2015年 / 8卷 / 08期
关键词：
Ginsenoside Rd; Nrf2/HO-1; myocardial ischemia-reperfusion injury; PRECONDITIONING PROTECTS; CEREBRAL-ISCHEMIA; ACTIVATION; STRESS; KEAP1; RATS; ISCHEMIA/REPERFUSION; CARDIOPROTECTION; INDUCTION; MECHANISM;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Ginsenoside Rd (GsRd) reportedly protects the heart against ischemia-reperfusion (I/R) injury. Nrf2/HO-1 signaling plays a key role in attenuating oxidative stress. However, it remains unclear whether GsRd protects against myocardial I/R injury via Nrf2/HO-1 signaling. This study aimed to investigate the role of Nrf2/HO-1 signaling in the cardioprotective effect of GsRd. Rats received 30 min ischemia followed by 2 h reperfusion. Cardiac function, infarct size and serum CK, LDH, cTnI levels were detected. The expression of Nrf2 and HO-1 was detected by western blot. The results suggested that GsRd attenuated myocardial I/R injury as evidenced by improved cardiac function, decreased infarct size and decreased levels of serum CK, LDH and cTnI. In addition, GsRd administration enhanced the expression of Nrf2 and HO-1. In conclusion, the present study shows that GsRd protects against myocardial I/R injury via Nrf2/HO-1 signaling.
引用
收藏
页码：14497 / 14504
页数：8
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