Synthesis, and antimicrobial evaluation of new pyridine imidazo [2,1b]-1,3,4-thiadiazole derivatives

被引：25

作者：

Bhardwaj, Varun ^{[1
]}

Noolvi, Malleshappa N. ^{[2
]}

Jalhan, Sunny ^{[3
]}

Patel, Harun M. ^{[4
]}

机构：

[1] Jaypee Univ Informat Technol, Dept Biotechnol Bioinformat & Pharm, Solan 173234, Himachal Prades, India

[2] Shree Dhanvantary Pharm Coll, Dept Pharmaceut Chem, Kim Surat 394110, Gujarat, India

[3] ASBASJSM Coll Pharm, Dept Pharmaceut Chem, Bela Ropar 140111, Punjab, India

[4] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut Chem, Shirpur Dhule 425405, Maharashtra, India

来源：

JOURNAL OF SAUDI CHEMICAL SOCIETY | 2016年 / 20卷

关键词：

Synthesis; Pyridine Imidazothiadiazole; Antimicrobial activity; 1,3,4-THIADIAZOLES; 1,2,4-TRIAZOLES; BEARING;

D O I：

10.1016/j.jscs.2012.12.007

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

With the aim of producing new biologically active compounds, a series of New Pyridine Imidazo [2,1b]-1,3,4-thiadiazole derivatives 4(a-k) were synthesized. All the compounds were characterized via IR, H-1-NMR and Mass spectral studies. The antimicrobial activity of newly synthesized compounds against various bacteria; Bacillus pumillus, Staphylococcus aureus, Vibrio cholera, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, and fungi; Candida albicans were evaluated. Among the compounds tested, 4(a), 4(b), 4(f), 4(h) and 4(k) exhibited good antimicrobial activity while others responded moderately with reference to standard drugs ampicillin and amphotericin B. (C) 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.

引用

页码：S406 / S410

页数：5

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